Extracellular matrix in vascular morphogenesis and disease: structure versus signal.

Abstract:

:The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signaling in establishing and maintaining the mature tubular structure. However, correlating cell signaling with established structural functions for the ECM and determining the relative importance of these two roles in vivo is often difficult. Here, we examine human genetics, murine gene targeting and cell biology to better understand the relationship between structural and signaling roles for the ECM in vascular morphogenesis and disease.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Brooke BS,Karnik SK,Li DY

doi

10.1016/s0962-8924(02)00007-7

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

51-6

issue

1

eissn

0962-8924

issn

1879-3088

pii

S0962892402000077

journal_volume

13

pub_type

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