Abstract:
:The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signaling in establishing and maintaining the mature tubular structure. However, correlating cell signaling with established structural functions for the ECM and determining the relative importance of these two roles in vivo is often difficult. Here, we examine human genetics, murine gene targeting and cell biology to better understand the relationship between structural and signaling roles for the ECM in vascular morphogenesis and disease.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Brooke BS,Karnik SK,Li DYdoi
10.1016/s0962-8924(02)00007-7subject
Has Abstractpub_date
2003-01-01 00:00:00pages
51-6issue
1eissn
0962-8924issn
1879-3088pii
S0962892402000077journal_volume
13pub_type
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