Abstract：
:Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin bridge interconnecting two daughter cells, can trigger the catastrophic pulverization of the spatially isolated chromosome. The resultant chromosomal fragments are religated in random order by DNA double-strand break repair during the subsequent interphase. Chromothripsis scars the cancer genome with localized DNA rearrangements that frequently generate extensive copy number alterations, oncogenic gene fusion products, and/or tumor suppressor gene inactivation. Here we review emerging mechanisms underlying chromothripsis with a focus on the contribution of cell division errors caused by centromere dysfunction.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Ly P,Cleveland DWdoi
10.1016/j.tcb.2017.08.005subject
Has Abstractpub_date
2017-12-01 00:00:00pages
917-930issue
12eissn
0962-8924issn
1879-3088pii
S0962-8924(17)30142-3journal_volume
27pub_type
杂志文章,评审abstract：:It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it...
journal_title：Trends in cell biology
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abstract：:The vast diversity of cellular types and behaviours is mainly the result of combinatorial interactions between a limited number of transcription factors and cellular signalling pathways whose activity is stringently controlled by developmental, cellular and extracellular cues. Studies of serum response factor (SRF) ha...
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2001-09-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2007-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2007-06-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.10.002
更新日期：2009-01-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2011.02.003
更新日期：2011-05-01 00:00:00
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更新日期：2018-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.03.001
更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
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更新日期：2016-03-01 00:00:00
