Abstract:
:The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleoprotein particle complexes). Unlike translocation across other organelle membranes, proteins do not have to be unfolded to be transported through the NPC, and the NPC also routinely transports large, multicomponent substrates in both directions. This review focuses on current understanding of the different mechanisms by which macromolecules move across the NPC.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Talcott B,Moore MSdoi
10.1016/s0962-8924(99)01608-6subject
Has Abstractpub_date
1999-08-01 00:00:00pages
312-8issue
8eissn
0962-8924issn
1879-3088pii
S0962-8924(99)01608-6journal_volume
9pub_type
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01658-x
更新日期:1999-11-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1999-03-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2009.11.006
更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01414-7
更新日期:1999-01-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(92)90246-j
更新日期:1992-07-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2003.11.004
更新日期:2004-01-01 00:00:00
abstract::The molecular mechanisms underlying targeted deposition of new membrane at the advancing furrow of a dividing cell have long been intriguing to cell biologists. Three recent studies have made use of Drosophila cellularization to explore current questions in this field. These findings indicate that both the secretory p...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2004.01.006
更新日期:2004-03-01 00:00:00
abstract::Microbiology has a long way to go. Microbes are ubiquitous, and all other life forms in the biosphere exist solely because of them, but, as less than 1% of microorganisms can be grown in the laboratory, more than a century of research has revealed only the tip of the iceberg concerning this most crucial of life scienc...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2006.10.004
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.10.011
更新日期:2013-03-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(00)01765-7
更新日期:2000-06-01 00:00:00
abstract::The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
abstract::A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2009.09.008
更新日期:2010-01-01 00:00:00
abstract::Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.10.008
更新日期:2013-02-01 00:00:00
abstract::The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2019.03.001
更新日期:2019-07-01 00:00:00
abstract::Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in th...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.08.001
更新日期:2012-11-01 00:00:00
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更新日期:2019-08-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2017.06.006
更新日期:2017-10-01 00:00:00
abstract::A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:1998-07-01 00:00:00