p53: new roles in metabolism.

abstract：:Most cells polarize in response to an asymmetric signal but some can spontaneously establish a discrete axis of polarity in the absence of a directional cue. Many mathematical models predict that locally acting positive feedback loops and globally acting negative regulators are required for pattern formation. Here, we...

journal_title：Trends in cell biology

authors： Sohrmann M,Peter M

更新日期：2003-10-01 00:00:00

abstract：:Formation of secretion granules in regulated secretory cells involves packaging a subject of proteins undergoing intracellular transport into specific vesicular carriers that function in stimulus-dependent exocytosis. Recent findings suggest that immature granules are a site of passive sorting, involving condensation ...

journal_title：Trends in cell biology

authors： Arvan P,Castle D

更新日期：1992-11-01 00:00:00

abstract：:Despite their small size and lack of obvious intracellular structures, bacteria have a complex and dynamic intracellular organization. Recent work has shown that many proteins, and even regions of the chromosome, are localized to specific subcellular regions that can change over time, sometimes extraordinarily fast. P...

journal_title：Trends in cell biology

authors： Jensen RB,Shapiro L

更新日期：2000-11-01 00:00:00

abstract：:To battle adverse internal and external conditions and maintain homeostasis, diploid organisms employ various cellular processes, such as proliferation and apoptosis. In some tissues, an alternative mechanism, endoreplication, is employed toward similar goals. Endoreplication is an evolutionarily conserved cell cycle ...

journal_title：Trends in cell biology

authors： Shu Z,Row S,Deng WM

更新日期：2018-06-01 00:00:00

abstract：:Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is generally understood that the oncogenic signaling pathways are overactivated, or at least abnormally activated, in cancer cells, important mechanistic details of such abnormal activation remain unresolved. Among these details are s...

journal_title：Trends in cell biology

authors： Zielińska KA,Katanaev VL

更新日期：2019-11-01 00:00:00

abstract：:Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

journal_title：Trends in cell biology

authors： Saffi GT,Botelho RJ

更新日期：2019-08-01 00:00:00

abstract：:The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. ...

journal_title：Trends in cell biology

authors： Bamburg JR,McGough A,Ono S

更新日期：1999-09-01 00:00:00

abstract：:Large-scale neurite pruning, the developmentally regulated degeneration of axons or dendrites, is an important specificity mechanism during neuronal circuit formation. Pruning is usually restricted to single neurite branches and can occur by local degeneration or retraction. How this spatial regulation is achieved, an...

journal_title：Trends in cell biology

authors： Rumpf S,Wolterhoff N,Herzmann S

更新日期：2019-04-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and ion storage. To maintain its function, it is turned over constitutively, and even more actively under certain stress conditions. Quality con...

journal_title：Trends in cell biology

authors： Chino H,Mizushima N

更新日期：2020-05-01 00:00:00

abstract：:Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...

journal_title：Trends in cell biology

authors： Johannes L,Goud B

更新日期：1998-04-01 00:00:00

abstract：:During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...

journal_title：Trends in cell biology

authors： Nankoe SR,Sever S

更新日期：2006-12-01 00:00:00

abstract：:Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and t...

journal_title：Trends in cell biology

authors： Davidson PM,Cadot B

更新日期：2020-12-26 00:00:00

abstract：:Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signallin...

journal_title：Trends in cell biology

authors： Ellis S,Mellor H

更新日期：2000-03-01 00:00:00

abstract：:Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated th...

journal_title：Trends in cell biology

authors： Wei C,Yu P,Cheng L

更新日期：2020-10-01 00:00:00

abstract：:It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it...

journal_title：Trends in cell biology

authors： Itoh K,Nakamura K,Iijima M,Sesaki H

更新日期：2013-02-01 00:00:00

abstract：:In essence, the mitotic cell cycle in eukaryotes involves the duplication and separation of chromosomes, coupled to the process of dividing one cell into two. Cytokinesis is therefore the culmination of a series of events that were triggered during G1 phase, and brings the daughter cells back to the starting position ...

journal_title：Trends in cell biology

authors： den Boer BG,Murray JA

更新日期：2000-06-01 00:00:00

abstract：:Living organisms undergo biochemical, physiological and behavioral cycles with periods ranging from seconds to years. Cycles with intermediate periods are governed by endogenous clocks that depend on oscillating gene expression. Here we illustrate the modalities and specific functions of post-transcriptional control o...

journal_title：Trends in cell biology

authors： Cibois M,Gautier-Courteille C,Legagneux V,Paillard L

更新日期：2010-09-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counte...

journal_title：Trends in cell biology

authors： Torraca V,Mostowy S

更新日期：2018-02-01 00:00:00

abstract：:Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone state. Despite this, UQ is also believed to be a membrane antioxidant. These properties place UQ at the center of hotly debated questions about how mi...

journal_title：Trends in cell biology

authors： Wang Y,Hekimi S

更新日期：2016-05-01 00:00:00

abstract：:Somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that they can maintain proliferative output while simultaneously protecting themselves from DNA damage that may lead to oncogenic transformation. There is considerable debate about how such stem cell compartments are organized. Burge...

journal_title：Trends in cell biology

authors： Yousefi M,Li L,Lengner CJ

更新日期：2017-10-01 00:00:00

abstract：:Ciliary movement is powered by axonemal dynein. This article considers how a signal transduction cascade initiated at the cell membrane may activate outer dynein arms to change the velocity of microtubule sliding and the swimming speed of ciliated cells. For Paramecium, a critical event in the cascade is the cAMP-depe...

journal_title：Trends in cell biology

authors： Satir P,Barkalow K,Hamasaki T

更新日期：1993-11-01 00:00:00

abstract：:Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate...

journal_title：Trends in cell biology

authors： Traylor-Knowles N,Palumbi SR

更新日期：2014-05-01 00:00:00

abstract：:Leukocytes are key cellular components of innate immunity. These phagocytic cells respond to bacteria at sites of infection through chemotactic sensing and directed motility regulated by Rho GTPases. The development of sensitive probes of Rho GTPase dynamics has provided insights into the temporal and spatial aspects ...

journal_title：Trends in cell biology

authors： Bokoch GM

更新日期：2005-03-01 00:00:00

abstract：:Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transforma...

journal_title：Trends in cell biology

authors： Bouchard C,Staller P,Eilers M

更新日期：1998-05-01 00:00:00

abstract：:The morphological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently. A prerequisite for each origin of multicellularity was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in comp...

journal_title：Trends in cell biology

authors： Abedin M,King N

更新日期：2010-12-01 00:00:00

abstract：:Across the animal kingdom, color discrimination is achieved by comparing the outputs of photoreceptor cells (PRs) that have different spectral sensitivities. Much remains to be understood about how the pattern of these different PRs is generated and maintained. The Drosophila eye has long provided a beautiful system f...

journal_title：Trends in cell biology

authors： Wernet MF,Desplan C

更新日期：2004-10-01 00:00:00

abstract：:Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...

journal_title：Trends in cell biology

authors： Greenberg MJ,Ostap EM

更新日期：2013-02-01 00:00:00

abstract：:A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is ...

journal_title：Trends in cell biology

authors： Odorizzi G,Cowles CR,Emr SD

更新日期：1998-07-01 00:00:00

abstract：:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...

journal_title：Trends in cell biology

authors： Dalal K,Duong F

更新日期：2011-09-01 00:00:00