Abstract：
:Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensely investigated. Much less is understood about lysosome fission, which is necessary to balance the incessant flow of cargo into lysosomes and maintain steady-state number, size, and function of lysosomes. Here, we review the emerging picture of how lipid signals, coat and adaptor proteins, and motor-cytoskeletal assemblies drive budding, tubulation, splitting, and 'kiss-and-run' events that enable fission and exit from lysosomes and related organelles.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Saffi GT,Botelho RJdoi
10.1016/j.tcb.2019.05.003subject
Has Abstractpub_date
2019-08-01 00:00:00pages
635-646issue
8eissn
0962-8924issn
1879-3088pii
S0962-8924(19)30082-0journal_volume
29pub_type
杂志文章,评审abstract：:The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...
journal_title：Trends in cell biology
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更新日期：1997-07-01 00:00:00
abstract：:The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells. During development, immune surveillance and disease states ranging from cancer to fibrosis, host cells penetrate the BM by engaging tissue-invasive programs, the ide...
journal_title：Trends in cell biology
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abstract：:Most microtubule arrays in animal cells, including the bipolar spindle required for cell division, are organized by centrosomes. Thus, strict control of centrosome numbers is crucial for accurate chromosome segregation. Each centrosome comprises two centrioles, which need to be duplicated exactly once in every cell cy...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2007.03.003
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abstract：:The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology...
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.10.002
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
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更新日期：2004-01-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2019-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2011.06.001
更新日期：2011-09-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/s0962-8924(00)88979-5
更新日期：1995-04-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2018.06.008
更新日期：2018-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2014.10.001
更新日期：2015-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2015.11.005
更新日期：2016-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.01.002
更新日期：2019-04-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.10.002
更新日期：2009-01-01 00:00:00
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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doi：10.1016/0962-8924(94)90189-9
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journal_title：Trends in cell biology
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doi：10.1016/0962-8924(92)90310-j
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journal_title：Trends in cell biology
pub_type： 杂志文章
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：1999-09-01 00:00:00
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2007.04.004
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abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...
journal_title：Trends in cell biology
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更新日期：1998-02-01 00:00:00
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章
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abstract：:There is a pronounced tendency among cell biologists to focus on qualitative aspects of cell physiology. The remarkable accomplishments of evolution in creating cells can only be fully appreciated, however, by combining this qualitative analysis with a quantitative assessment of cellular constituents and processes. He...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(01)02030-x
更新日期：2001-07-01 00:00:00
