Abstract:
:Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has often been restricted to functions of the modifying enzymes, rather than to histones as ADP-ribose acceptors. In particular, the identification of specific lysine residues as ADP-ribose acceptor sites in histones and the identification of ADP-ribose binding modules raise this modification to a par with acetylation, methylation or phosphorylation. We discuss here the functional aspects of histone ADP-ribosylation and its influence on DNA repair, replication and transcription.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Messner S,Hottiger MOdoi
10.1016/j.tcb.2011.06.001subject
Has Abstractpub_date
2011-09-01 00:00:00pages
534-42issue
9eissn
0962-8924issn
1879-3088pii
S0962-8924(11)00106-1journal_volume
21pub_type
杂志文章,评审abstract::Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...
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