Abstract：
:Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan. Other chondrodystrophies are testimony to the importance of post-translational modifications. Here, Barbara Vertel reviews the role of aggrecan in the ECM of cartilage, discusses genetic mutations affecting aggrecan and highlights intracellular features of its synthesis and processing.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Vertel BMdoi
10.1016/s0962-8924(00)89115-1subject
Has Abstractpub_date
1995-12-01 00:00:00pages
458-64issue
12eissn
0962-8924issn
1879-3088pii
S0962892400891151journal_volume
5pub_type
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