Abstract:
:Luke and colleagues have recently attributed a new role to a member of the serpin superfamily of serine proteinase inhibitors. They have used Caenorhabditis elegans to show that an intracellular serpin is crucial for maintaining lysosomal integrity. We examine the role of this firewall in preventing necrosis and attempt to integrate this with current theories of stress-induced protein degradation. We discuss how mutant serpins cause disease either through polymerization or now, perhaps, by unleashing necrosis.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Marciniak SJ,Lomas DAdoi
10.1016/j.tcb.2007.11.006subject
Has Abstractpub_date
2008-02-01 00:00:00pages
45-7issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(08)00017-2journal_volume
18pub_type
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