Abstract：
:Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand known functional capacities of microtubule (MT) polymers. One such innovation - the ventral disc - is a cup-shaped MT organelle that the parasite Giardia uses to attach to the small intestine of its host. The molecular mechanisms underlying the generation of suction-based forces by overall conformational changes of the disc remain unclear. The elaborate disc architecture is defined by novel proteins and complexes that decorate almost all disc MT protofilaments, and vary in composition and conformation along the length of the MTs. Future genetic, biochemical, and functional analyses of disc-associated proteins will be central toward understanding not only disc architecture and assembly, but also the overall disc conformational dynamics that promote attachment.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Nosala C,Hagen KD,Dawson SCdoi
10.1016/j.tcb.2017.10.007subject
Has Abstractpub_date
2018-02-01 00:00:00pages
99-112issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(17)30198-8journal_volume
28pub_type
杂志文章,评审abstract：:A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (T...
journal_title：Trends in cell biology
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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