Abstract：
:Intracellular bacteria including major pathogens live in the cytoplasm or in cytoplasmic vacuoles within their host cell. However, some can invade more unusual intracellular niches such as the eukaryotic nucleus. Phylogenetically diverse intranuclear bacteria have been discovered in various protist, arthropod, marine invertebrate, and mammalian hosts. Although targeting the same cellular compartment, they have apparently developed fundamentally-different infection strategies. The nucleus provides a rich pool of nutrients and protection against host cytoplasmic defense mechanisms; intranuclear bacteria can directly manipulate the host by interfering with nuclear processes. The impact on their host cells ranges from stable associations with a neutral or beneficial effect on host fitness to rapid host lysis. The analysis of the intranuclear lifestyle will extend our current framework for understanding host-pathogen interactions.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Schulz F,Horn Mdoi
10.1016/j.tcb.2015.01.002subject
Has Abstractpub_date
2015-06-01 00:00:00pages
339-46issue
6eissn
0962-8924issn
1879-3088pii
S0962-8924(15)00013-6journal_volume
25pub_type
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