Abstract:
:Leukocytes are key cellular components of innate immunity. These phagocytic cells respond to bacteria at sites of infection through chemotactic sensing and directed motility regulated by Rho GTPases. The development of sensitive probes of Rho GTPase dynamics has provided insights into the temporal and spatial aspects of GTPase regulation during chemotaxis and subsequent microbial phagocytosis. The resulting destruction of ingested bacteria by means of reactive oxygen species (ROS) depends on a Rac-regulated "molecular switch" that is modulated by antagonistic crosstalk involving Cdc42. Recent studies of leukocytes derived from Rac1- and Rac2-knockout mice have shown that these highly homologous GTPases have unique biological roles. An understanding of the biochemical basis for such distinct activities should provide novel insights into the molecular details of Rho GTPase function and regulation in innate immunity.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Bokoch GMdoi
10.1016/j.tcb.2005.01.002subject
Has Abstractpub_date
2005-03-01 00:00:00pages
163-71issue
3eissn
0962-8924issn
1879-3088pii
S0962-8924(05)00016-4journal_volume
15pub_type
杂志文章,评审abstract::The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2020.08.005
更新日期:2020-11-01 00:00:00
abstract::The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylatio...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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abstract::Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely com...
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
abstract::Understanding the basic mechanisms underlying chromatin dynamics during DNA replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction, chromatin organization represents a means to regulate genome function. Thus, the inheritance and maintenance of the DNA sequence, along with its organization ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2008.10.002
更新日期:2009-01-01 00:00:00
abstract::A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (T...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2008.06.005
更新日期:2008-08-01 00:00:00
abstract::During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2006.10.004
更新日期:2006-12-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2019.11.002
更新日期:2020-02-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(96)10035-0
更新日期:1996-10-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2018.08.005
更新日期:2019-01-01 00:00:00
abstract::Cyclin-dependent kinase 2 (CDK2) regulates diverse aspects of the mammalian cell cycle. Most cancer cells contain mutations in the pathways that control CDK2, and CDK2 activity has received much attention as a target for cancer therapy. However, a recent report demonstrating that some cancer cells can proliferate with...
journal_title:Trends in cell biology
pub_type: 评论,杂志文章
doi:10.1016/s0962-8924(03)00148-x
更新日期:2003-08-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.03.001
更新日期:2011-07-01 00:00:00
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journal_title:Trends in cell biology
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abstract::Transfer of proteins and lipids between the various membrane-bound subcellular compartments of the eukaryotic cell is mediated by transport vesicles. The development of cell-free assays has allowed rapid progress towards a molecular description of the formation, or budding, of these vesicles. This article reviews and ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(91)90018-5
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2018.02.006
更新日期:2018-06-01 00:00:00
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journal_title:Trends in cell biology
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doi:10.1016/j.tcb.2006.07.006
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abstract::Land plants have developed highly sophisticated intercellular channels called plasmodesmata (PD) that mediate the cell-to-cell trafficking of signaling molecules, including non-cell autonomous proteins (NCAPs) and RNAs. Until recently, the biological significance of this position-dependent intercellular signaling syst...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2009.07.003
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2015.06.003
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abstract::A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated prote...
journal_title:Trends in cell biology
pub_type: 评论,杂志文章
doi:10.1016/j.tcb.2017.09.003
更新日期:2017-11-01 00:00:00
abstract::The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2006.11.003
更新日期:2007-01-01 00:00:00
abstract::Membrane trafficking pathways function to sort and transport cargoes to various intracellular compartments and to the plasma membrane. This allows precise spatiotemporal control of processes such as signal transduction, which in turn is crucial for complex cell functions such as cell division, migration and polarity. ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.02.003
更新日期:2011-05-01 00:00:00
abstract::Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1alpha (HIF-1alp...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
abstract::Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discu...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(97)01217-8
更新日期:1998-03-01 00:00:00