Abstract:
:To battle adverse internal and external conditions and maintain homeostasis, diploid organisms employ various cellular processes, such as proliferation and apoptosis. In some tissues, an alternative mechanism, endoreplication, is employed toward similar goals. Endoreplication is an evolutionarily conserved cell cycle program during which cells replicate their genomes without division, resulting in polyploid cells. Importantly, endoreplication is reported to be indispensable for normal development and organ formation across various organisms, from fungi to humans. In recent years, more attention has been drawn to delineating its connections to wound healing and tumorigenesis. In this Review, we discuss mechanisms of endoreplication and polyploidization, their essential and positive roles in normal development and tissue homeostasis, and the relationship between polyploidy and cancer.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Shu Z,Row S,Deng WMdoi
10.1016/j.tcb.2018.02.006subject
Has Abstractpub_date
2018-06-01 00:00:00pages
465-474issue
6eissn
0962-8924issn
1879-3088pii
S0962-8924(18)30030-8journal_volume
28pub_type
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