Abstract：
:Endosomal protein sorting governs the fate of many physiologically important proteins involved in a panoply of cellular functions. Recent discoveries have revealed a vital role for endosomally localised branched actin patches in facilitating protein sorting. The formation of the actin patches has been shown to require the function of the WASH complex - the major endosomal actin polymerisation-promoting complex - which stimulates the activity of the ubiquitously expressed Arp2/3 complex. Another key component of the endosomal protein-sorting machinery is the retromer complex. Studies now show that retromer mediates the recruitment of the WASH complex and its regulators to endosomes. In this review, recent progress in understanding the role of the WASH complex along with retromer in endosomal protein sorting is discussed.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Seaman MN,Gautreau A,Billadeau DDdoi
10.1016/j.tcb.2013.04.010subject
Has Abstractpub_date
2013-11-01 00:00:00pages
522-8issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(13)00083-4journal_volume
23pub_type
杂志文章,评审abstract：:Actin is an ancient and abundant protein with well-established roles in fundamental processes ranging from cell migration to membrane transport. Most eukaryotic cells also contain at least eight actin-related proteins (ARPs) that are, themselves, conserved between organisms as divergent as yeast and mammals. Although ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2004.05.007
更新日期：2004-07-01 00:00:00
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2021-01-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2011.04.005
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2015.11.005
更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
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更新日期：2001-12-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.07.004
更新日期：2012-10-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2007.11.006
更新日期：2008-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.08.005
更新日期：2020-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(96)84934-8
更新日期：1996-12-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.11.005
更新日期：2020-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
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更新日期：2005-03-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2006-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...
journal_title：Trends in cell biology
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更新日期：2016-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.08.004
更新日期：2019-11-01 00:00:00
