Abstract:
:The vast diversity of cellular types and behaviours is mainly the result of combinatorial interactions between a limited number of transcription factors and cellular signalling pathways whose activity is stringently controlled by developmental, cellular and extracellular cues. Studies of serum response factor (SRF) have provided a paradigm for such interactions for some years. Recent advances have shown that two families of SRF cofactors, the ternary complex factors (TCFs) and the myocardin-related transcription factors (MTRFs), are regulated by separate signalling pathways and thereby control SRF target genes differentially. The actin cytoskeleton is both an upstream regulator of MRTF activity, with monomeric actin directly acting as a signal transducer, and a downstream effector, because of the many cytoskeletal target genes. Here we discuss how the competition among cofactors might integrate these distinct signalling pathways into a specific transcriptional response and biological function.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Posern G,Treisman Rdoi
10.1016/j.tcb.2006.09.008subject
Has Abstractpub_date
2006-11-01 00:00:00pages
588-96issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(06)00269-8journal_volume
16pub_type
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