Cycling without CDK2?

abstract：:The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular signaling events. Although these proteins do not have enzymatic or transcriptional activity, they spatially and temporally control signaling events through their ability to undergo changes in phosphorylation and to associate w...

journal_title：Trends in cell biology

authors： Defilippi P,Di Stefano P,Cabodi S

更新日期：2006-05-01 00:00:00

abstract：:Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientifi...

journal_title：Trends in cell biology

authors： Slepchenko BM,Schaff JC,Macara I,Loew LM

更新日期：2003-11-01 00:00:00

abstract：:The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylatio...

journal_title：Trends in cell biology

authors： Bard F,Chia J

更新日期：2016-05-01 00:00:00

abstract：:'Secrete-and-sense cells' can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially 'talk' to itself ('self-communication') or talk to neighboring cells with the same receptor ('neighbor communication'). The predominant forms of secrete-and-se...

journal_title：Trends in cell biology

authors： Doğaner BA,Yan LKQ,Youk H

更新日期：2016-04-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. ...

journal_title：Trends in cell biology

authors： Bamburg JR,McGough A,Ono S

更新日期：1999-09-01 00:00:00

abstract：:Luke and colleagues have recently attributed a new role to a member of the serpin superfamily of serine proteinase inhibitors. They have used Caenorhabditis elegans to show that an intracellular serpin is crucial for maintaining lysosomal integrity. We examine the role of this firewall in preventing necrosis and attem...

journal_title：Trends in cell biology

authors： Marciniak SJ,Lomas DA

更新日期：2008-02-01 00:00:00

abstract：:The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...

journal_title：Trends in cell biology

authors： Guo W,Novick P

更新日期：2004-02-01 00:00:00

abstract：:Whereas physics seeks for universal laws underlying natural phenomena, biology accounts for complexity and specificity of molecular details. Contemporary biological physics requires people capable of working at this interface. New programs prepare scientists who transform respective disciplinary views into innovative ...

journal_title：Trends in cell biology

authors： Riveline D,Kruse K

更新日期：2017-08-01 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology...

journal_title：Trends in cell biology

authors： Kimata Y

更新日期：2019-07-01 00:00:00

abstract：:Intracellular bacteria including major pathogens live in the cytoplasm or in cytoplasmic vacuoles within their host cell. However, some can invade more unusual intracellular niches such as the eukaryotic nucleus. Phylogenetically diverse intranuclear bacteria have been discovered in various protist, arthropod, marine ...

journal_title：Trends in cell biology

authors： Schulz F,Horn M

更新日期：2015-06-01 00:00:00

abstract：:The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membr...

journal_title：Trends in cell biology

authors： Pettitt JM,van Driel IR,Toh BH,Gleeson PA

更新日期：1996-02-01 00:00:00

abstract：:Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can le...

journal_title：Trends in cell biology

authors： Bischoff JR,Plowman GD

更新日期：1999-11-01 00:00:00

abstract：:Substantial progress has been made in recent years toward understanding the molecular mechanisms by which tumor cells, and the supporting stroma, degrade confining matrix during migration. Significant attention has been focused on understanding the biology of several dynamic and distinct, but remarkably related, cell ...

journal_title：Trends in cell biology

authors： McNiven MA

更新日期：2013-01-01 00:00:00

abstract：:All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has allowed bone marrow transplantation to become a routine clinical option. Successful transplantation requires haemopoietic stem cells...

journal_title：Trends in cell biology

authors： Whetton AD,Graham GJ

更新日期：1999-06-01 00:00:00

abstract：:An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...

journal_title：Trends in cell biology

authors： Romanowski P,Madine MA

更新日期：1996-05-01 00:00:00

abstract：:A deeper understanding of the mechanisms of cell behavior is essential if we want to comprehend how an organism develops and functions. Changes in cellular processes, including the orientation of cell divisions, cell shape, polarity, differentiation and migration, account for tissue rearrangements during development a...

journal_title：Trends in cell biology

authors： Beis D,Stainier DY

更新日期：2006-02-01 00:00:00

abstract：:The proteins reggie-1 and reggie-2 were originally discovered in neurons during axon regeneration. Subsequently, they were independently identified as markers of lipid rafts in flotation assays and were hence named flotillins. Since then, reggie/flotillin proteins have been found to be evolutionarily conserved and are...

journal_title：Trends in cell biology

authors： Stuermer CA

更新日期：2010-01-01 00:00:00

abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

journal_title：Trends in cell biology

authors： Goldstein B,King N

更新日期：2016-11-01 00:00:00

abstract：:Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is ...

journal_title：Trends in cell biology

authors： Amson R,Pece S,Marine JC,Di Fiore PP,Telerman A

更新日期：2013-01-01 00:00:00

abstract：:The role o f iron in cell division, cell death and human disease has recently gained increased attention. The best studied process for iron uptake into mammalian cells involves traps ferrin and its receptor. This review discusses evidence supporting the existence of other routes by which iron can enter mammalian cells...

journal_title：Trends in cell biology

authors： Jefferies WA,Gabathuler R,Rothenberger S,Food M,Kennard ML

更新日期：1996-06-01 00:00:00

abstract：:Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in the protection and lubrication of luminal epithelial surfaces. Transmembrane mucins also engage in signal transduction, through extracellular domain-mediated ligand binding or by interacting with receptors for growth and differe...

journal_title：Trends in cell biology

authors： Singh PK,Hollingsworth MA

更新日期：2006-09-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family member...

journal_title：Trends in cell biology

authors： Cohen P

更新日期：1997-09-01 00:00:00

abstract：:The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...

journal_title：Trends in cell biology

authors： A R,Tyson JR,Stirling CJ

更新日期：1997-07-01 00:00:00

abstract：:The vast diversity of cellular types and behaviours is mainly the result of combinatorial interactions between a limited number of transcription factors and cellular signalling pathways whose activity is stringently controlled by developmental, cellular and extracellular cues. Studies of serum response factor (SRF) ha...

journal_title：Trends in cell biology

authors： Posern G,Treisman R

更新日期：2006-11-01 00:00:00

abstract：:During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

journal_title：Trends in cell biology

authors： Sonneveld S,Verhagen BMP,Tanenbaum ME

更新日期：2020-08-01 00:00:00

abstract：:Until recently, the cell biology of mammalian muscle repair following damage appeared to be completely different from the formation of new muscles in regenerated appendages of Amphibia. Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage rege...

journal_title：Trends in cell biology

authors： Slack JM

更新日期：2006-06-01 00:00:00

abstract：:Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we re...

journal_title：Trends in cell biology

authors： Yan J,Horng T

更新日期：2020-12-01 00:00:00

abstract：:Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone state. Despite this, UQ is also believed to be a membrane antioxidant. These properties place UQ at the center of hotly debated questions about how mi...

journal_title：Trends in cell biology

authors： Wang Y,Hekimi S

更新日期：2016-05-01 00:00:00

abstract：:Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to ...

journal_title：Trends in cell biology

authors： Rajyaguru P,Parker R

更新日期：2009-01-01 00:00:00