Abstract：
:All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has allowed bone marrow transplantation to become a routine clinical option. Successful transplantation requires haemopoietic stem cells to home to the bone marrow, leave the peripheral circulation and become stabilized in regulatory niches in the extravascular space of the bone marrow cavity. This homing and tethering process is reversible - haemopoietic stem cells can be released from their bone marrow tethering through changes in molecular interactions, which are also important in homing following transplantation. The molecular mechanisms regulating this two-way flow of stem cells are beginning to be elucidated, and much recent data has emerged that sheds light on the processes and molecules involved in these complex physiological events. This article reviews current knowledge of the adhesive, homing and proliferative influences acting on HSCs and progenitor cells.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Whetton AD,Graham GJdoi
10.1016/s0962-8924(99)01559-7subject
Has Abstractpub_date
1999-06-01 00:00:00pages
233-8issue
6eissn
0962-8924issn
1879-3088pii
S0962892499015597journal_volume
9pub_type
杂志文章,评审abstract：:Cell biologists have used photobleaching to investigate the lateral mobility of fluorophores on the cell surface since the 1970s. Fusions of green fluorescent protein (GFP) to specific proteins extend photobleaching techniques to the investigation of protein dynamics within the cell, leading to renewed interest in pho...
journal_title：Trends in cell biology
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pub_type： 传,历史文章,杂志文章,评审
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更新日期：1999-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
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doi：10.1016/s0962-8924(00)88933-3
更新日期：1995-01-01 00:00:00
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journal_title：Trends in cell biology
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更新日期：2004-05-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.05.008
更新日期：2009-08-01 00:00:00
abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...
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