Abstract：
:Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditions, and during apoptosis. However, cristae were considered to be largely static entities. Recently, advanced super-resolution techniques have revealed that cristae are independent bioenergetic units that are highly dynamic and remodel on a timescale of seconds. These advances, coupled with mechanistic and structural studies on key molecular players, such as the MICOS (mitochondrial contact site and cristae organizing system) complex and the dynamin-like GTPase OPA1, have changed our view on mitochondria in a fundamental way. We summarize these recent findings and discuss their functional implications.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Kondadi AK,Anand R,Reichert ASdoi
10.1016/j.tcb.2020.08.008subject
Has Abstractpub_date
2020-12-01 00:00:00pages
923-936issue
12eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30169-0journal_volume
30pub_type
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