Abstract：
:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA. One challenge in studying poly(A) tails is that they are difficult to sequence and accurately measure. However, recent advances in sequencing technology, computational algorithms, and other assays have enabled a more detailed look at poly(A) tail length genome-wide throughout many developmental stages and organisms. With the help of these advances, our understanding of poly(A) tail length has evolved over the past 5 years with the recognition that highly expressed genes can have short poly(A) tails and the elucidation of the seemingly contradictory roles for poly(A)-binding protein (PABP) in facilitating both protection and deadenylation.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Nicholson AL,Pasquinelli AEdoi
10.1016/j.tcb.2018.11.002subject
Has Abstractpub_date
2019-03-01 00:00:00pages
191-200issue
3eissn
0962-8924issn
1879-3088pii
S0962-8924(18)30188-0journal_volume
29pub_type
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