Tales of Detailed Poly(A) Tails.


:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA. One challenge in studying poly(A) tails is that they are difficult to sequence and accurately measure. However, recent advances in sequencing technology, computational algorithms, and other assays have enabled a more detailed look at poly(A) tail length genome-wide throughout many developmental stages and organisms. With the help of these advances, our understanding of poly(A) tail length has evolved over the past 5 years with the recognition that highly expressed genes can have short poly(A) tails and the elucidation of the seemingly contradictory roles for poly(A)-binding protein (PABP) in facilitating both protection and deadenylation.


Trends Cell Biol


Trends in cell biology


Nicholson AL,Pasquinelli AE




Has Abstract


2019-03-01 00:00:00














  • A New Paradigm in Catalase Research.

    abstract::Recent findings provide evidence for dynamic and highly regulated dual subcellular localization of catalase, a hydrogen peroxide (H2O2)-metabolizing enzyme, in peroxisomes and the cytosol. These data suggest a number of important implications for the field of oxidative stress biology. ...

    journal_title:Trends in cell biology

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    authors: Fujiki Y,Bassik MC

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  • Homing and mobilization in the stem cell niche.

    abstract::All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has allowed bone marrow transplantation to become a routine clinical option. Successful transplantation requires haemopoietic stem cells...

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  • New regulatory mechanisms of TGF-beta receptor function.

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  • The SecY complex: conducting the orchestra of protein translocation.

    abstract::Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...

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    authors: Dalal K,Duong F

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    authors: Hecht PM,Anderson KV

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  • Lysosomes nor Mice Move Forward without Borcs7.

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  • Protein sorting and secretion granule formation in regulated secretory cells.

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    authors: Arvan P,Castle D

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  • Dissecting clathrin-coated pits.

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    authors: Bétermier M,Borde V,de Villartay JP

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  • Interface between Physics and Biology: Training a New Generation of Creative Bilingual Scientists.

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    authors: Kolesnick R

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    authors: Carragher NO,Frame MC

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    abstract::Intracellular bacteria including major pathogens live in the cytoplasm or in cytoplasmic vacuoles within their host cell. However, some can invade more unusual intracellular niches such as the eukaryotic nucleus. Phylogenetically diverse intranuclear bacteria have been discovered in various protist, arthropod, marine ...

    journal_title:Trends in cell biology

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    authors: Schulz F,Horn M

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  • Time To Split Up: Dynamics of Chromosome Separation.

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    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kamenz J,Hauf S

    更新日期:2017-01-01 00:00:00

  • Peroxisome turnover by micropexophagy: an autophagy-related process.

    abstract::Many organisms stringently regulate the number, volume and enzymatic content of peroxisomes (and other organelles). Understanding this regulation requires knowledge of how organelles are assembled and selectively destroyed in response to metabolic cues. In the past decade, considerable progress has been achieved in th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Farré JC,Subramani S

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  • Protein Sorting within Chloroplasts.

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    authors: Xu X,Ouyang M,Lu D,Zheng C,Zhang L

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  • Signal transduction during mating and meiosis in S. pombe.

    abstract::When starved, the fission yeast Schizosaccharomyces pombe responds by producing mating factors or pheromones that signal to cells of the opposite sex to initiate mating. Like its distant relative Saccharomyces cerevisiae, cells of the two mating types of S. pombe each produce a distinct pheromone that binds to recepto...

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    authors: Nielsen O

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  • Building a retinal mosaic: cell-fate decision in the fly eye.

    abstract::Across the animal kingdom, color discrimination is achieved by comparing the outputs of photoreceptor cells (PRs) that have different spectral sensitivities. Much remains to be understood about how the pattern of these different PRs is generated and maintained. The Drosophila eye has long provided a beautiful system f...

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    authors: Wernet MF,Desplan C

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  • Lymphocyte recirculation and homing: roles of adhesion molecules and chemoattractants.

    abstract::Lymphocyte migration from high endothelial venules into lymphoid organs is mediated by a sequence of interactions between cell adhesion molecules on lymphocytes and those on the vascular endothelial cells that line the vessels. recent studies suggest that the so-called lymphocyte homing receptors and vascular addressi...

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    authors: Ager A

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  • The relevance of apoptosis to AIDS pathogenesis.

    abstract::Several recent experimental findings support the hypothesis that apoptosis induced by human immune deficiency virus (HIV) is important in the pathogenesis of acquired immune deficiency syndrome (AIDS). Thus, one potential therapeutic strategy against AIDS may be to block the HIV-mediated apoptosis signal transduction ...

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    authors: Ameisen JC,Estaquier J,Idziorek T,De Bels F

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  • Virtual gating and nuclear transport: the hole picture.

    abstract::The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules a...

    journal_title:Trends in cell biology

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    authors: Rout MP,Aitchison JD,Magnasco MO,Chait BT

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  • RGS proteins: more than just GAPs for heterotrimeric G proteins.

    abstract::Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude...

    journal_title:Trends in cell biology

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    authors: De Vries L,Gist Farquhar M

    更新日期:1999-04-01 00:00:00

  • Principles of selective transport: coat complexes hold the key.

    abstract::The transport of protein through the secretory pathway of eukaryotic cells relies on small vesicular carriers, which mediate the movement of cargo between different compartments. Here, Meir Aridor and Bill Balch summarize what is currently known about the role of the cytosolic coat complexes in directing the formation...

    journal_title:Trends in cell biology

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    authors: Aridor M,Balch WE

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  • Heterogeneity in mRNA Translation.

    abstract::During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

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    authors: Sonneveld S,Verhagen BMP,Tanenbaum ME

    更新日期:2020-08-01 00:00:00

  • LPA: a novel lipid mediator with diverse biological actions.

    abstract::Lysophosphatidic acid (LPA), the smallest and structurally simplest phospholipid, is a platelet-derived serum factor that evokes a wide range of biological effects, including stimulation of fibroblast proliferation, platelet aggregation, cellular motility, tumour cell invasiveness and neurite retraction. This review s...

    journal_title:Trends in cell biology

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    authors: Moolenaar WH

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  • The Future of Cell Biology: Emerging Model Organisms.

    abstract::Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Goldstein B,King N

    更新日期:2016-11-01 00:00:00

  • Cyclophilins: a new family of proteins involved in intracellular folding.

    abstract::Proteins of the cyclophilin family display two intriguing properties. On the one hand, they are the intracellular receptors for the immunosuppressive drug cyclosporin A (CsA); on the other hand, they function in vitro as enzymes that catalyse slow steps in protein folding. A dissection of the role of CsA in mediating ...

    journal_title:Trends in cell biology

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    authors: Stamnes MA,Rutherford SL,Zuker CS

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  • The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation.

    abstract::Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Tornatore L,Thotakura AK,Bennett J,Moretti M,Franzoso G

    更新日期:2012-11-01 00:00:00