Tales of Detailed Poly(A) Tails.


:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA. One challenge in studying poly(A) tails is that they are difficult to sequence and accurately measure. However, recent advances in sequencing technology, computational algorithms, and other assays have enabled a more detailed look at poly(A) tail length genome-wide throughout many developmental stages and organisms. With the help of these advances, our understanding of poly(A) tail length has evolved over the past 5 years with the recognition that highly expressed genes can have short poly(A) tails and the elucidation of the seemingly contradictory roles for poly(A)-binding protein (PABP) in facilitating both protection and deadenylation.


Trends Cell Biol


Trends in cell biology


Nicholson AL,Pasquinelli AE




Has Abstract


2019-03-01 00:00:00














  • Extracellular matrix in vascular morphogenesis and disease: structure versus signal.

    abstract::The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signali...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Brooke BS,Karnik SK,Li DY

    更新日期:2003-01-01 00:00:00

  • Photoreceptor Discs: Built Like Ectosomes.

    abstract::The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Spencer WJ,Lewis TR,Pearring JN,Arshavsky VY

    更新日期:2020-11-01 00:00:00

  • The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?

    abstract::The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Guo W,Novick P

    更新日期:2004-02-01 00:00:00

  • pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1.

    abstract::Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identifi...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Capasso M,DeCoursey TE,Dyer MJ

    更新日期:2011-01-01 00:00:00

  • Raf: the holy grail of Ras biology?

    abstract::Ras proteins regulate cell growth and differentiation, and their mutation plays a major, direct role in causing human cancer. For years, their precise function has been a mystery. One of the pathways Ras controls has recently been identified. It consists of a cascade of kinases (Raf, MEK and MAP kinases) that transmit...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: McCormick F

    更新日期:1994-10-01 00:00:00

  • Feeling green: mechanosensing in plants.

    abstract::Owing to the sessile nature of their lifestyle, plants have to respond to a wide range of signals, such as the force of the wind or the impedance of the soil, to entrain their development to prevailing environmental conditions. Indeed, mechanically responsive growth has been documented in plants for many years but new...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Monshausen GB,Gilroy S

    更新日期:2009-05-01 00:00:00

  • Nonclassical protein sorting.

    abstract::Recent characterization of the major protein-targeting systems in both yeast and mammalian cells has provided detailed descriptions of how cellular transport processes operate. Increasingly, however, novel protein-sorting mechanisms are being uncovered. These newly discovered 'alternative' mechanisms of protein sortin...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Klionsky DJ

    更新日期:1997-06-01 00:00:00

  • Assembly and transport of seed storage proteins.

    abstract::Plant seeds store nitrogen by accumulating storage proteins in protein bodies within various compartments of the endomembrane system. The prolamin storage proteins of some cereal species are normally retained and assembled into protein bodies within the ER. Yet, these proteins lack a C-terminal KDEL/HDEL signal, sugge...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Galili G,Altschuler Y,Levanony H

    更新日期:1993-12-01 00:00:00

  • Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

    abstract::Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in m...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Clarke PR,Zhang C

    更新日期:2001-09-01 00:00:00

  • A novel subfamily of Hsp70s in the endoplasmic reticulum.

    abstract::The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: A R,Tyson JR,Stirling CJ

    更新日期:1997-07-01 00:00:00

  • Membrane Architecture in the Spotlight of Correlative Microscopy.

    abstract::Cellular membranes differ in their molecular organisation, shape, and dynamics. Knowing how these properties of membrane architecture relate to the presence and function of specific membrane components is fundamental for understanding membrane-associated cellular processes. Correlative light and electron microscopy (C...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ganeva I,Kukulski W

    更新日期:2020-07-01 00:00:00

  • Sorting nuclear membrane proteins at mitosis.

    abstract::The nuclear envelope (NE) breaks down reversibly and reassembles at mitosis. Two models of mitotic nuclear membrane disassembly and reformation have emerged from studies of NE dynamics in somatic cells and egg extracts. One model suggests that nuclear membranes fragment reversibly by vesiculation, producing NE-derived...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Collas P,Courvalin JC

    更新日期:2000-01-01 00:00:00

  • Compartmentalization of the nucleus.

    abstract::The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Meldi L,Brickner JH

    更新日期:2011-12-01 00:00:00

  • Metastasis Stemming from Circulating Tumor Cell Clusters.

    abstract::Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcripti...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Yu M

    更新日期:2019-04-01 00:00:00

  • Caveolae: anchored, multifunctional platforms in the lipid ocean.

    abstract::The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitri...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: van Deurs B,Roepstorff K,Hommelgaard AM,Sandvig K

    更新日期:2003-02-01 00:00:00

  • Regulation of membrane traffic by integrin signaling.

    abstract::Membrane trafficking pathways function to sort and transport cargoes to various intracellular compartments and to the plasma membrane. This allows precise spatiotemporal control of processes such as signal transduction, which in turn is crucial for complex cell functions such as cell division, migration and polarity. ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Wickström SA,Fässler R

    更新日期:2011-05-01 00:00:00

  • The nuclear connection in RNA transport and localization.

    abstract::RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport. Many of these proteins bind several RNA targets and have multiple functions. In this review we focus on RNA-binding proteins that are implicated in RNA transport ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Farina KL,Singer RH

    更新日期:2002-10-01 00:00:00

  • Proteostasis impairment in protein-misfolding and -aggregation diseases.

    abstract::Cells possess an extensive network of components to safeguard proteome integrity and maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines in performance, as may be the case during aging, newly synthesized proteins are no longer able to fold efficiently and metastable proteins lose ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Hipp MS,Park SH,Hartl FU

    更新日期:2014-09-01 00:00:00

  • Classical and Nonclassical Intercellular Communication in Senescence and Ageing.

    abstract::Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Fafián-Labora JA,O'Loghlen A

    更新日期:2020-08-01 00:00:00

  • Turning up the Green Light.

    abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Cassereau J,Courdavault V,Nägerl UV

    更新日期:2020-12-29 00:00:00

  • Regulation of endocytic traffic by rho family GTPases.

    abstract::Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signallin...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ellis S,Mellor H

    更新日期:2000-03-01 00:00:00

  • Golgi disassembly in apoptosis: cause or effect?

    abstract::The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Machamer CE

    更新日期:2003-06-01 00:00:00

  • Exploring the caves: cavins, caveolins and caveolae.

    abstract::Caveolae are ampullate (flask-shaped) invaginations that are abundant in the plasma membrane of many mammalian cell types. Although caveolae are implicated in a wide range of processes including endothelial transcytosis, lipid homeostasis and cellular signalling, a detailed molecular picture of many aspects of their f...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Hansen CG,Nichols BJ

    更新日期:2010-04-01 00:00:00

  • The search for physiological substrates of MAP and SAP kinases in mammalian cells.

    abstract::Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family member...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Cohen P

    更新日期:1997-09-01 00:00:00

  • Genetic tags for labelling live cells: gap junctions and beyond.

    abstract::The availability of green fluorescent protein (GFP) as a tracer for observing proteins in living cells has revolutionized cell biology and spurred an intensive search for GFP variants with novel characteristics, additional autofluorescent proteins and alternative techniques of protein labelling. Two recent studies - o...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Falk M

    更新日期:2002-09-01 00:00:00

  • Getting across the nuclear pore complex.

    abstract::The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleopr...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Talcott B,Moore MS

    更新日期:1999-08-01 00:00:00

  • The Golgi apparatus: 100 years of progress and controversy.

    abstract::Research on the Golgi apparatus has resulted in major advances in understanding its structure and functions, but many important questions remain unanswered. The history of the Golgi apparatus has been marked by arguments and controversies, some of which have been resolved, whereas others are still ongoing. This articl...

    journal_title:Trends in cell biology

    pub_type: 传,历史文章,杂志文章,评审


    authors: Farquhar MG,Palade GE

    更新日期:1998-01-01 00:00:00

  • The spindle checkpoint: two transitions, two pathways.

    abstract::The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Gardner RD,Burke DJ

    更新日期:2000-04-01 00:00:00

  • Germline cysts: a conserved phase of germ cell development?

    abstract::Germ cells in many vertebrate and invertebrate species initiate gametogenesis by forming groups of interconnected cells known as germline cysts. Recent studies using Xenopus, mouse and Drosophila are beginning to uncover the cellular and molecular mechanisms that control germline cyst formation and, in conjunction wit...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Pepling ME,de Cuevas M,Spradling AC

    更新日期:1999-07-01 00:00:00

  • Triggering the cell cycle in plants.

    abstract::In essence, the mitotic cell cycle in eukaryotes involves the duplication and separation of chromosomes, coupled to the process of dividing one cell into two. Cytokinesis is therefore the culmination of a series of events that were triggered during G1 phase, and brings the daughter cells back to the starting position ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: den Boer BG,Murray JA

    更新日期:2000-06-01 00:00:00