Tales of Detailed Poly(A) Tails.

Abstract:

:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA. One challenge in studying poly(A) tails is that they are difficult to sequence and accurately measure. However, recent advances in sequencing technology, computational algorithms, and other assays have enabled a more detailed look at poly(A) tail length genome-wide throughout many developmental stages and organisms. With the help of these advances, our understanding of poly(A) tail length has evolved over the past 5 years with the recognition that highly expressed genes can have short poly(A) tails and the elucidation of the seemingly contradictory roles for poly(A)-binding protein (PABP) in facilitating both protection and deadenylation.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Nicholson AL,Pasquinelli AE

doi

10.1016/j.tcb.2018.11.002

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

191-200

issue

3

eissn

0962-8924

issn

1879-3088

pii

S0962-8924(18)30188-0

journal_volume

29

pub_type

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