Post-transcriptional controls - adding a new layer of regulation to clock gene expression.

Abstract:

:Living organisms undergo biochemical, physiological and behavioral cycles with periods ranging from seconds to years. Cycles with intermediate periods are governed by endogenous clocks that depend on oscillating gene expression. Here we illustrate the modalities and specific functions of post-transcriptional control of gene expression (exerted on pre-mRNAs and mRNAs) in biological clocks through two examples: the circadian clock and the vertebrate somite segmentation clock, an embryonic clock with a period far below a day. We conclude that both constitutive and cyclic post-transcriptional controls underpin clock function.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Cibois M,Gautier-Courteille C,Legagneux V,Paillard L

doi

10.1016/j.tcb.2010.06.004

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

533-41

issue

9

eissn

0962-8924

issn

1879-3088

pii

S0962-8924(10)00119-4

journal_volume

20

pub_type

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