Joining the cell survival squad: an emerging role for protein kinase CK2.

abstract：:Cells possess an extensive network of components to safeguard proteome integrity and maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines in performance, as may be the case during aging, newly synthesized proteins are no longer able to fold efficiently and metastable proteins lose ...

journal_title：Trends in cell biology

authors： Hipp MS,Park SH,Hartl FU

更新日期：2014-09-01 00:00:00

abstract：:Vesicular transport of proteins and lipids between distinct subcellular compartments is directly responsible for generating and maintaining the structure of the organelles of the secretory and endocytic pathways in eukaryotic cells. Rapid advances in a variety of experimental systems have resulted in the identificatio...

journal_title：Trends in cell biology

authors： Sztul ES,Melançon P,Howell KE

更新日期：1992-12-01 00:00:00

abstract：:Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process o f asymmetric cell division can be described as consisting of three steps: setting up an asymmetric c...

journal_title：Trends in cell biology

authors： Gönczy P,Hyman AA

更新日期：1996-10-01 00:00:00

abstract：:Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate...

journal_title：Trends in cell biology

authors： Traylor-Knowles N,Palumbi SR

更新日期：2014-05-01 00:00:00

abstract：:The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...

journal_title：Trends in cell biology

authors： A R,Tyson JR,Stirling CJ

更新日期：1997-07-01 00:00:00

abstract：:Chloroplasts have multiple suborganellar membranes. Correct and efficient translocation of chloroplast proteins from their site of synthesis into or across membranes to their functional compartments are fundamental processes. In recent years, several new components and regulatory mechanisms involved in chloroplast pro...

journal_title：Trends in cell biology

authors： Xu X,Ouyang M,Lu D,Zheng C,Zhang L

更新日期：2021-01-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:It is well established that the target of rapamycin (TOR) protein kinase has pivotal roles in controlling cell functions (including protein synthesis, cell growth and cell proliferation) and is implicated in numerous human diseases. Mammalian TOR complex 1 (mTORC1) signalling is activated by hormones and growth factor...

journal_title：Trends in cell biology

authors： Wang X,Proud CG

更新日期：2009-06-01 00:00:00

abstract：:Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identifi...

journal_title：Trends in cell biology

authors： Capasso M,DeCoursey TE,Dyer MJ

更新日期：2011-01-01 00:00:00

abstract：:The morphological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently. A prerequisite for each origin of multicellularity was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in comp...

journal_title：Trends in cell biology

authors： Abedin M,King N

更新日期：2010-12-01 00:00:00

abstract：:How do the many different components of an organelle assemble into a functional structure at an appropriate place and time? Flagellar regeneration by the biflagellate green alga Chlamydomonas is one experimental system in which genetics, biochemistry and ultrastructural analysis are being combined to investigate the a...

journal_title：Trends in cell biology

authors： Johnson KA,Rosenbaum JL

更新日期：1993-05-01 00:00:00

abstract：:The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signali...

journal_title：Trends in cell biology

authors： Brooke BS,Karnik SK,Li DY

更新日期：2003-01-01 00:00:00

abstract：:Scientific research relies on a range of technologies, many of which are developing at a fast pace. Technical experts able to advise researchers on experimental design and validate the performance1 of shared instruments are increasingly recognized as critical members of the research community. Here I describe a novel ...

journal_title：Trends in cell biology

authors： Waters JC

更新日期：2020-09-01 00:00:00

abstract：:The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM he...

journal_title：Trends in cell biology

authors： Labib K,Gambus A

更新日期：2007-06-01 00:00:00

abstract：:Lymphocyte migration from high endothelial venules into lymphoid organs is mediated by a sequence of interactions between cell adhesion molecules on lymphocytes and those on the vascular endothelial cells that line the vessels. recent studies suggest that the so-called lymphocyte homing receptors and vascular addressi...

journal_title：Trends in cell biology

authors： Ager A

更新日期：1994-09-01 00:00:00

abstract：:In essence, the mitotic cell cycle in eukaryotes involves the duplication and separation of chromosomes, coupled to the process of dividing one cell into two. Cytokinesis is therefore the culmination of a series of events that were triggered during G1 phase, and brings the daughter cells back to the starting position ...

journal_title：Trends in cell biology

authors： den Boer BG,Murray JA

更新日期：2000-06-01 00:00:00

abstract：:Sphingomyelin used to be considered only as a structural molecule of the outer leaflet of the plasma membrane of mammalian cells. However, in the last five years it has become clear that sphingomyelin is rapidly degraded and resynthesized in a pathway that could function in signal transduction. Indeed, it is now known...

journal_title：Trends in cell biology

authors： Kolesnick R

更新日期：1992-08-01 00:00:00

abstract：:A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule requir...

journal_title：Trends in cell biology

authors： Gallet A

更新日期：2011-04-01 00:00:00

abstract：:Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...

journal_title：Trends in cell biology

authors： Otani T,Furuse M

更新日期：2020-10-01 00:00:00

abstract：:Microtubules have been regarded as essential structures for stable neuronal morphology but new studies are highlighting their role in dynamic neuronal processes. Recent work demonstrates that the microtubule cytoskeleton has an active role during different phases of neuronal polarization - microtubules and their stabi...

journal_title：Trends in cell biology

authors： Hoogenraad CC,Bradke F

更新日期：2009-12-01 00:00:00

abstract：:The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regula...

journal_title：Trends in cell biology

authors： Kamenz J,Hauf S

更新日期：2017-01-01 00:00:00

abstract：:The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...

journal_title：Trends in cell biology

authors： Needleman D

更新日期：2015-12-01 00:00:00

abstract：:Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude...

journal_title：Trends in cell biology

authors： De Vries L,Gist Farquhar M

更新日期：1999-04-01 00:00:00

abstract：:Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emp...

journal_title：Trends in cell biology

authors： Vallee RB,Seale GE,Tsai JW

更新日期：2009-07-01 00:00:00

abstract：:The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors...

journal_title：Trends in cell biology

authors： Linggi B,Carpenter G

更新日期：2006-12-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...

journal_title：Trends in cell biology

authors： Kanaar R,Hoeijmakers JH,van Gent DC

更新日期：1998-12-01 00:00:00

abstract：:Damage to any tissue triggers a cascade of events that leads to rapid repair of the wound - if the tissue is skin, then repair involves re-epithelialization, formation of granulation tissue and contraction of underlying wound connective tissues. This concerted effort by the wounded cell layers is accompanied by, and m...

journal_title：Trends in cell biology

authors： Martin P,Leibovich SJ

更新日期：2005-11-01 00:00:00

abstract：:Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is generally understood that the oncogenic signaling pathways are overactivated, or at least abnormally activated, in cancer cells, important mechanistic details of such abnormal activation remain unresolved. Among these details are s...

journal_title：Trends in cell biology

authors： Zielińska KA,Katanaev VL

更新日期：2019-11-01 00:00:00

abstract：:The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

journal_title：Trends in cell biology

authors： Wang F,Higgins JM

更新日期：2013-04-01 00:00:00

abstract：:Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant ...

journal_title：Trends in cell biology

authors： Odle RI,Florey O,Ktistakis NT,Cook SJ

更新日期：2021-02-01 00:00:00