pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1.

Abstract:

:Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identification of unanticipated and diverse functions: HVCN1 not only modulates signaling from the B-cell receptor following B-cell activation and histamine release from basophils, but also mediates pH-dependent activation of spermatozoa, as well as acid secretion by tracheal epithelium. The importance of HVCN1 in pH regulation during phagocytosis was established by surprising evidence that indicated its first-responder role. In this review, we discuss recent findings from a functional perspective, and the potential of HVCN1 as a therapeutic target for autoimmune and other diseases.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Capasso M,DeCoursey TE,Dyer MJ

doi

10.1016/j.tcb.2010.09.006

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

20-8

issue

1

eissn

0962-8924

issn

1879-3088

pii

S0962-8924(10)00200-X

journal_volume

21

pub_type

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