Abstract:
:Lymphocyte migration from high endothelial venules into lymphoid organs is mediated by a sequence of interactions between cell adhesion molecules on lymphocytes and those on the vascular endothelial cells that line the vessels. recent studies suggest that the so-called lymphocyte homing receptors and vascular addressins regulate the first stages of this process, that of binding of lymphocytes from flowing blood. The subsequent crawling of lymphocytes over the endothelial cell surface and migration across the vessel wall (diapedesis) are regulated independently of initial binding. These latter stages are thought to be mediated by functional activation of integrins on the lymphocyte by chemoattractants located in the vessel wall.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Ager Adoi
10.1016/0962-8924(94)90234-8subject
Has Abstractpub_date
1994-09-01 00:00:00pages
326-33issue
9eissn
0962-8924issn
1879-3088pii
0962892494902348journal_volume
4pub_type
杂志文章abstract::Somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that they can maintain proliferative output while simultaneously protecting themselves from DNA damage that may lead to oncogenic transformation. There is considerable debate about how such stem cell compartments are organized. Burge...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2017.06.006
更新日期:2017-10-01 00:00:00
abstract::Cellular organization of the cytoskeleton, assembly of intracellular signaling complexes and movement of membrane receptors into supramolecular activation complexes (SMACs) are crucial prerequisites for lymphocyte activation and function. Full T-cell activation requires costimulatory signals in addition to antigen-med...
journal_title:Trends in cell biology
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abstract::Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...
journal_title:Trends in cell biology
pub_type: 评论,杂志文章
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01658-x
更新日期:1999-11-01 00:00:00
abstract::Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2017.04.005
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abstract::The mechanisms responsible for cytokinesis and its coordination with other events of the cell cycle are poorly understood. Genetic studies of cytokinesis in fission yeast are one useful approach to this problem. A number of conditional mutants of fission yeast that show defects in the formation of the septum of cytoki...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(94)90182-1
更新日期:1994-03-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2017.10.007
更新日期:2018-02-01 00:00:00
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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更新日期:2020-02-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-beta family proteins signal through Smads to induce changes in gene expr...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01710-9
更新日期:2000-03-01 00:00:00
abstract::The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour and orchestrate functions of cells in tissue formation and homeostasis. The composition of the ECM, its three-dimensional organization and proteolytic remodelling are major determinants of the microenvironmental signalling context tha...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01362-2
更新日期:1998-11-01 00:00:00
abstract::The number of invited women speakers at scientific meetings is much less than their proportion in a field. This means that women have fewer venues to present their research, less opportunity to increase their professional network, and smaller chances of promotion and financial support. The paucity of women speakers al...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2015.06.001
更新日期:2015-08-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(94)90144-9
更新日期:1994-06-01 00:00:00
abstract::Owing to the sessile nature of their lifestyle, plants have to respond to a wide range of signals, such as the force of the wind or the impedance of the soil, to entrain their development to prevailing environmental conditions. Indeed, mechanically responsive growth has been documented in plants for many years but new...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2009.02.005
更新日期:2009-05-01 00:00:00
abstract::While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2009.09.009
更新日期:2010-01-01 00:00:00
abstract::It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular diseases, and cancer in tissue culture an...
journal_title:Trends in cell biology
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更新日期:2012-10-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
abstract::Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has ofte...
journal_title:Trends in cell biology
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doi:10.1016/j.tcb.2011.06.001
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
abstract::All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has allowed bone marrow transplantation to become a routine clinical option. Successful transplantation requires haemopoietic stem cells...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01559-7
更新日期:1999-06-01 00:00:00
abstract::The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genomic instability, whi...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2019.06.005
更新日期:2019-09-01 00:00:00
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journal_title:Trends in cell biology
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doi:10.1016/j.tcb.2016.07.008
更新日期:2017-01-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(92)90181-l
更新日期:1992-11-01 00:00:00
abstract::The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2006.11.003
更新日期:2007-01-01 00:00:00
abstract::Diabetes is a metabolic disease affecting nearly 300 million individuals worldwide. Both types of diabetes (1 and 2) are characterized by loss of functional pancreatic β-cell mass causing different degrees of insulin deficiency. The Bcl-2 family has a double-edged effect in diabetes. These proteins are crucial control...
journal_title:Trends in cell biology
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2009.08.006
更新日期:2009-12-01 00:00:00
abstract::Research performed over the past decade has transformed apoptosis from a distinctive form of cell death known only by its characteristic morphology and genomic destruction to an increasingly well understood cellular disassembly pathway remarkable for its complex and multifaceted regulation. Here, we summarize current ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(01)02173-0
更新日期:2001-12-01 00:00:00