Abstract：
:Phagocytosis is a receptor-mediated, actin-dependent process of internalization of large extracellular particles, such as pathogens or apoptotic cells. Engulfment of phagocytic targets requires the activity of myosins, actin-dependent molecular motors, which perform a variety of functions at distinct steps during phagocytosis. By applying force to actin filaments, the plasma membrane, and intracellular proteins and organelles, myosins can generate contractility, directly regulate actin assembly to ensure proper phagocytic internalization, and translocate phagosomes or other cargo to appropriate cellular locations. Recent studies using engineered microenvironments and phagocytic targets have demonstrated how altering the actomyosin cytoskeleton affects phagocytic behavior. Here, we discuss how studies using genetic and biochemical manipulation of myosins, force measurement techniques, and live-cell imaging have advanced our understanding of how specific myosins function at individual steps of phagocytosis.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Barger SR,Gauthier NC,Krendel Mdoi
10.1016/j.tcb.2019.11.002subject
Has Abstractpub_date
2020-02-01 00:00:00pages
157-167issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(19)30198-9journal_volume
30pub_type
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