Maturation of cytosolic and nuclear iron-sulfur proteins.

abstract：:Bidirectional microtubule-dependent organelle transport in melanophores is regulated by cAMP through organelle-bound protein kinase A (PKA); however, the mechanisms responsible for this regulation are unknown. A recent study by Gelfand and colleagues demonstrates that, in addition to PKA, transport is regulated by the...

journal_title：Trends in cell biology

authors： Kashina A,Rodionov V

更新日期：2005-08-01 00:00:00

abstract：:Endocytosis is essential for the entry of many viruses into cells. The primate lentiviruses [human immunodeficiency virus (HIV) 1 and 2, and the simian immunodeficiency viruses (SIVs)], however, use endocytosis in other aspects of their life cycles. Here, the authors describe the ways in which the endocytic pathway is...

journal_title：Trends in cell biology

authors： Marsh M,Pelchen-Matthews A,Hoxie JA

更新日期：1997-01-01 00:00:00

abstract：:Cancer is a multistage process requiring progressive genetic and epigenetic changes in neoplastic and responding stromal cells. Many alterations that occur during the process of malignant progression are regulated by the matrix metalloproteinase (MMP) family of extracellular proteases and their endogenous inhibitors. ...

journal_title：Trends in cell biology

authors： Rhee JS,Coussens LM

更新日期：2002-05-01 00:00:00

abstract：:Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering...

journal_title：Trends in cell biology

authors： Huang P,Oliff A

更新日期：2001-08-01 00:00:00

abstract：:While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the...

journal_title：Trends in cell biology

authors： Barlow CA,Laishram RS,Anderson RA

更新日期：2010-01-01 00:00:00

abstract：:Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in the protection and lubrication of luminal epithelial surfaces. Transmembrane mucins also engage in signal transduction, through extracellular domain-mediated ligand binding or by interacting with receptors for growth and differe...

journal_title：Trends in cell biology

authors： Singh PK,Hollingsworth MA

更新日期：2006-09-01 00:00:00

abstract：:Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process o f asymmetric cell division can be described as consisting of three steps: setting up an asymmetric c...

journal_title：Trends in cell biology

authors： Gönczy P,Hyman AA

更新日期：1996-10-01 00:00:00

abstract：:The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...

journal_title：Trends in cell biology

authors： Guo W,Novick P

更新日期：2004-02-01 00:00:00

abstract：:Substantial progress has been made in recent years toward understanding the molecular mechanisms by which tumor cells, and the supporting stroma, degrade confining matrix during migration. Significant attention has been focused on understanding the biology of several dynamic and distinct, but remarkably related, cell ...

journal_title：Trends in cell biology

authors： McNiven MA

更新日期：2013-01-01 00:00:00

abstract：:The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...

journal_title：Trends in cell biology

authors： Storz P

更新日期：2007-01-01 00:00:00

abstract：:Scientific research relies on a range of technologies, many of which are developing at a fast pace. Technical experts able to advise researchers on experimental design and validate the performance1 of shared instruments are increasingly recognized as critical members of the research community. Here I describe a novel ...

journal_title：Trends in cell biology

authors： Waters JC

更新日期：2020-09-01 00:00:00

abstract：:Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

journal_title：Trends in cell biology

authors： Saffi GT,Botelho RJ

更新日期：2019-08-01 00:00:00

abstract：:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

journal_title：Trends in cell biology

authors： Nicholson AL,Pasquinelli AE

更新日期：2019-03-01 00:00:00

abstract：:Several recent experimental findings support the hypothesis that apoptosis induced by human immune deficiency virus (HIV) is important in the pathogenesis of acquired immune deficiency syndrome (AIDS). Thus, one potential therapeutic strategy against AIDS may be to block the HIV-mediated apoptosis signal transduction ...

journal_title：Trends in cell biology

authors： Ameisen JC,Estaquier J,Idziorek T,De Bels F

更新日期：1995-01-01 00:00:00

abstract：:The mechanisms responsible for cytokinesis and its coordination with other events of the cell cycle are poorly understood. Genetic studies of cytokinesis in fission yeast are one useful approach to this problem. A number of conditional mutants of fission yeast that show defects in the formation of the septum of cytoki...

journal_title：Trends in cell biology

authors： Fankhauser C,Simanis V

更新日期：1994-03-01 00:00:00

abstract：:Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

journal_title：Trends in cell biology

authors： Joshi U,Houwman JA,van der Sluijs P

更新日期：2018-10-01 00:00:00

abstract：:After nearly four decades of investigation, the dynein motor is finally on the verge of revealing its inner secrets. This multisubunit ATPase participates in several important microtubule-based motilities in eukaryotic cells. Numerous recent articles have advanced the understanding of the dynein motor substructure and...

journal_title：Trends in cell biology

authors： Koonce MP,Samsó M

更新日期：2004-11-01 00:00:00

abstract：:Most cells polarize in response to an asymmetric signal but some can spontaneously establish a discrete axis of polarity in the absence of a directional cue. Many mathematical models predict that locally acting positive feedback loops and globally acting negative regulators are required for pattern formation. Here, we...

journal_title：Trends in cell biology

authors： Sohrmann M,Peter M

更新日期：2003-10-01 00:00:00

abstract：:In essence, the mitotic cell cycle in eukaryotes involves the duplication and separation of chromosomes, coupled to the process of dividing one cell into two. Cytokinesis is therefore the culmination of a series of events that were triggered during G1 phase, and brings the daughter cells back to the starting position ...

journal_title：Trends in cell biology

authors： den Boer BG,Murray JA

更新日期：2000-06-01 00:00:00

abstract：:Synaptic junctions are highly specialized structures designed to promote the rapid and efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane within the central nervous system. Proteins containing PDZ domains play a fundamental organizational role at both the pre- and postsynaptic...

journal_title：Trends in cell biology

authors： Garner CC,Nash J,Huganir RL

更新日期：2000-07-01 00:00:00

abstract：:Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

journal_title：Trends in cell biology

authors： Fafián-Labora JA,O'Loghlen A

更新日期：2020-08-01 00:00:00

abstract：:Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditi...

journal_title：Trends in cell biology

authors： Kondadi AK,Anand R,Reichert AS

更新日期：2020-12-01 00:00:00

abstract：:Transfer of proteins and lipids between the various membrane-bound subcellular compartments of the eukaryotic cell is mediated by transport vesicles. The development of cell-free assays has allowed rapid progress towards a molecular description of the formation, or budding, of these vesicles. This article reviews and ...

journal_title：Trends in cell biology

authors： Melançon P,Franzusoff A,Howell KE

更新日期：1991-12-01 00:00:00

abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

journal_title：Trends in cell biology

authors： Goldstein B,King N

更新日期：2016-11-01 00:00:00

abstract：:Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and, specifically, within the chromatin-associated fraction. Consistent with their localization, many lncRNAs have been implicated in ...

journal_title：Trends in cell biology

authors： Quinodoz S,Guttman M

更新日期：2014-11-01 00:00:00

abstract：:Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan. Other chondrodystrophies are te...

journal_title：Trends in cell biology

authors： Vertel BM

更新日期：1995-12-01 00:00:00

abstract：:Members of the transforming growth factor-beta (TGF-beta) family play pivotal roles in development and disease. These cytokines elicit their pleiotropic effects on cells, including endothelial and mural cells, through specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription fa...

journal_title：Trends in cell biology

authors： Pardali E,Goumans MJ,ten Dijke P

更新日期：2010-09-01 00:00:00

abstract：:The progress of a cell through its growth cycle is a multifaceted process; so far we have seen only a glimpse of the complex interplay between the macromolecules performing and regulating the different steps involved. In most organisms, control mechanisms ensure that all chromosomal DNA sequences are replicated once, ...

journal_title：Trends in cell biology

authors： Boye E

更新日期：1991-11-01 00:00:00

abstract：:The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. ...

journal_title：Trends in cell biology

authors： Bamburg JR,McGough A,Ono S

更新日期：1999-09-01 00:00:00

abstract：:A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule requir...

journal_title：Trends in cell biology

authors： Gallet A

更新日期：2011-04-01 00:00:00