The relevance of apoptosis to AIDS pathogenesis.

abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...

journal_title：Trends in cell biology

authors： Norton JD,Deed RW,Craggs G,Sablitzky F

更新日期：1998-02-01 00:00:00

abstract：:Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

journal_title：Trends in cell biology

authors： Fafián-Labora JA,O'Loghlen A

更新日期：2020-08-01 00:00:00

abstract：:Long-distance cell-cell communication is essential for organ development and function. Whereas neurons communicate at long distances by transferring signals at sites of direct contact (i.e., at synapses), it has been presumed that the only way other cell types signal is by dispersing signals through extracellular flui...

journal_title：Trends in cell biology

authors： Kornberg TB,Roy S

更新日期：2014-06-01 00:00:00

abstract：:Phagocytosis is a receptor-mediated, actin-dependent process of internalization of large extracellular particles, such as pathogens or apoptotic cells. Engulfment of phagocytic targets requires the activity of myosins, actin-dependent molecular motors, which perform a variety of functions at distinct steps during phag...

journal_title：Trends in cell biology

authors： Barger SR,Gauthier NC,Krendel M

更新日期：2020-02-01 00:00:00

abstract：:Living organisms undergo biochemical, physiological and behavioral cycles with periods ranging from seconds to years. Cycles with intermediate periods are governed by endogenous clocks that depend on oscillating gene expression. Here we illustrate the modalities and specific functions of post-transcriptional control o...

journal_title：Trends in cell biology

authors： Cibois M,Gautier-Courteille C,Legagneux V,Paillard L

更新日期：2010-09-01 00:00:00

abstract：:Nuclear proteins are transported from the cytoplasm into the nucleus via nuclear envelope pore complexes (NPCs). At the molecular level, the mechanisms responsible for this transport remain obscure. However, it is known that, for many proteins, the process requires ATP and proceeds against formidable nucleocytoplasmic...

journal_title：Trends in cell biology

authors： Paine PL

更新日期：1993-10-01 00:00:00

abstract：:Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support th...

journal_title：Trends in cell biology

authors： Bose S,Ramesh V,Locasale JW

更新日期：2019-09-01 00:00:00

abstract：:Epithelial cells comprise the foundation for the majority of organs in the mammalian body, and are the source of approximately 90% of all human cancers. Characteristically, epithelial cells form intercellular adhesions, exhibit apical/basal polarity, and orient their mitotic spindles in the plane of the epithelial she...

journal_title：Trends in cell biology

authors： McCaffrey LM,Macara IG

更新日期：2011-12-01 00:00:00

abstract：:Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and t...

journal_title：Trends in cell biology

authors： Davidson PM,Cadot B

更新日期：2020-12-26 00:00:00

abstract：:The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...

journal_title：Trends in cell biology

authors： Guo W,Novick P

更新日期：2004-02-01 00:00:00

abstract：:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...

journal_title：Trends in cell biology

authors： Budi EH,Duan D,Derynck R

更新日期：2017-09-01 00:00:00

abstract：:Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoev...

journal_title：Trends in cell biology

authors： Galluzzi L,Spranger S,Fuchs E,López-Soto A

更新日期：2019-01-01 00:00:00

abstract：:Vascular barrier function is controlled at cell-cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms contro...

journal_title：Trends in cell biology

authors： Lagendijk AK,Yap AS,Hogan BM

更新日期：2018-03-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic potential. Nevertheless, programmed DSBs (prDSBs) contribute to several biological processes. Formation of prDSBs is the 'price to pay' to achieve these essential biological functions. Generated by domesticated PiggyBac transposases, ...

journal_title：Trends in cell biology

authors： Bétermier M,Borde V,de Villartay JP

更新日期：2020-02-01 00:00:00

abstract：:Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different. I...

journal_title：Trends in cell biology

authors： D'Angiolella V,Esencay M,Pagano M

更新日期：2013-03-01 00:00:00

abstract：:The annual meeting of the American Society for Cell Biology (ASCB) is a large and diverse gathering. At last year's meeting**The American Society for Cell Biology 38th Annual Meeting, San Francisco, USA; 12-16 December, 1998. Program chair: Jennifer Lippincott-Schwartz., there were over 8000 attendees, and the topics ...

journal_title：Trends in cell biology

authors： Lee G

更新日期：1999-03-01 00:00:00

abstract：:Endocytosis is essential for the entry of many viruses into cells. The primate lentiviruses [human immunodeficiency virus (HIV) 1 and 2, and the simian immunodeficiency viruses (SIVs)], however, use endocytosis in other aspects of their life cycles. Here, the authors describe the ways in which the endocytic pathway is...

journal_title：Trends in cell biology

authors： Marsh M,Pelchen-Matthews A,Hoxie JA

更新日期：1997-01-01 00:00:00

abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...

journal_title：Trends in cell biology

authors： Wilson EK

更新日期：2001-11-01 00:00:00

abstract：:Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely com...

journal_title：Trends in cell biology

authors： Choo KH

更新日期：2000-05-01 00:00:00

abstract：:Gene editing in zebrafish has begun to reveal discordance between mutant phenotypes and those associated with knockdown via morpholino oligonucleotides (MOs). These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene functi...

journal_title：Trends in cell biology

authors： Lawson ND

更新日期：2016-02-01 00:00:00

abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...

journal_title：Trends in cell biology

authors： Baas PW,Ahmad FJ

更新日期：2001-06-01 00:00:00

abstract：:The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitri...

journal_title：Trends in cell biology

authors： van Deurs B,Roepstorff K,Hommelgaard AM,Sandvig K

更新日期：2003-02-01 00:00:00

abstract：:The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...

journal_title：Trends in cell biology

authors： A R,Tyson JR,Stirling CJ

更新日期：1997-07-01 00:00:00

abstract：:Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...

journal_title：Trends in cell biology

authors： Temple MD,Perrone GG,Dawes IW

更新日期：2005-06-01 00:00:00

abstract：:Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditi...

journal_title：Trends in cell biology

authors： Kondadi AK,Anand R,Reichert AS

更新日期：2020-12-01 00:00:00

abstract：:Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discu...

journal_title：Trends in cell biology

authors： Wasserman S

更新日期：1998-03-01 00:00:00

abstract：:Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF,...

journal_title：Trends in cell biology

authors： Pao KC,Rape M

更新日期：2019-10-01 00:00:00

abstract：:The power of fluorescence microscopy to study cellular structures and macromolecular complexes spans a wide range of size scales, from studies of cell behavior and function in physiological 3D environments to understanding the molecular architecture of organelles. At each length scale, the challenge in 3D imaging is t...

journal_title：Trends in cell biology

authors： Fischer RS,Wu Y,Kanchanawong P,Shroff H,Waterman CM

更新日期：2011-12-01 00:00:00

abstract：:Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a ...

journal_title：Trends in cell biology

authors： Ortega N,Behonick DJ,Werb Z

更新日期：2004-02-01 00:00:00

abstract：:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

journal_title：Trends in cell biology

authors： Nicholson AL,Pasquinelli AE

更新日期：2019-03-01 00:00:00