Abstract:
:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization of the cytoskeleton whereas bouts of retraction involve depolymerization of the cytoskeleton. Here we present an alternative view, namely that molecular motor proteins generate forces on the cytoskeletal polymers that can affect their distribution and configuration. In this view, bouts of axonal elongation involve net forward movement of cytoskeletal elements whereas bouts of retraction involve net backward movements. We propose that environmental cues elicit bouts of elongation or retraction via biochemical pathways that modulate the activities of relevant motors.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Baas PW,Ahmad FJdoi
10.1016/s0962-8924(01)02005-0subject
Has Abstractpub_date
2001-06-01 00:00:00pages
244-9issue
6eissn
0962-8924issn
1879-3088pii
S0962-8924(01)02005-0journal_volume
11pub_type
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