Building a retinal mosaic: cell-fate decision in the fly eye.

Abstract:

:Across the animal kingdom, color discrimination is achieved by comparing the outputs of photoreceptor cells (PRs) that have different spectral sensitivities. Much remains to be understood about how the pattern of these different PRs is generated and maintained. The Drosophila eye has long provided a beautiful system for understanding various aspects of retinal-cell differentiation. Recent progress in this field is revealing that a highly ordered series of events, involving cell-cell communication, localized signaling and stochastic choices, creates a complex mosaic of PRs that is reminiscent of the human retina. Notably, several of the factors used in generating the retinal mosaic of the fruitfly have corresponding functions in vertebrates that are likely to have similar roles.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Wernet MF,Desplan C

doi

10.1016/j.tcb.2004.09.007

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

576-84

issue

10

eissn

0962-8924

issn

1879-3088

pii

S0962-8924(04)00239-9

journal_volume

14

pub_type

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