The Different Routes to Metastasis via Hypoxia-Regulated Programs.

Abstract:

:Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JA

doi

10.1016/j.tcb.2018.06.008

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

941-956

issue

11

eissn

0962-8924

issn

1879-3088

pii

S0962-8924(18)30109-0

journal_volume

28

pub_type

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