Abstract：
:Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JAdoi
10.1016/j.tcb.2018.06.008subject
Has Abstractpub_date
2018-11-01 00:00:00pages
941-956issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(18)30109-0journal_volume
28pub_type
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