Abstract：
:Studies of the HEDGEHOG signalling pathway in Drosophila have revealed a functional link between two genes, cubitus interruptus and patched, whose human homologues are, respectively, a proto-oncogene and a tumour suppressor. While the former has been implicated as a transcription factor, controversy has surrounded the function of the transmembrane protein encoded by the latter. Somewhere in the signal-transduction pathway between these two lies protein kinase A (PKA), and now SMOOTHENED, whose similarity to G-protein-coupled receptors suggests a link with PKA, has also been implicated in the pathway. This article summarizes the current understanding of the pathway and the interactions between these proteins.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
van den Heuvel M,Ingham PWdoi
10.1016/0962-8924(96)84934-8subject
Has Abstractpub_date
1996-12-01 00:00:00pages
451-3issue
12eissn
0962-8924issn
1879-3088pii
0962892496849348journal_volume
6pub_type
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