Protecting the Aging Genome.

abstract：:In response to stress, p53 initiates the transcriptional regulation of selected target genes and various cellular responses, including cell cycle arrest, apoptosis and senescence. Recent studies revealed two additional functions of p53 in the regulation of IGF-1/AKT/mTOR pathways and energy metabolism, contributing to...

journal_title：Trends in cell biology

authors： Feng Z,Levine AJ

更新日期：2010-07-01 00:00:00

abstract：:Diabetes is a metabolic disease affecting nearly 300 million individuals worldwide. Both types of diabetes (1 and 2) are characterized by loss of functional pancreatic β-cell mass causing different degrees of insulin deficiency. The Bcl-2 family has a double-edged effect in diabetes. These proteins are crucial control...

journal_title：Trends in cell biology

authors： Gurzov EN,Eizirik DL

更新日期：2011-07-01 00:00:00

abstract：:The number of invited women speakers at scientific meetings is much less than their proportion in a field. This means that women have fewer venues to present their research, less opportunity to increase their professional network, and smaller chances of promotion and financial support. The paucity of women speakers al...

journal_title：Trends in cell biology

authors： Masur SK

更新日期：2015-08-01 00:00:00

abstract：:Microtubules have been regarded as essential structures for stable neuronal morphology but new studies are highlighting their role in dynamic neuronal processes. Recent work demonstrates that the microtubule cytoskeleton has an active role during different phases of neuronal polarization - microtubules and their stabi...

journal_title：Trends in cell biology

authors： Hoogenraad CC,Bradke F

更新日期：2009-12-01 00:00:00

abstract：:The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membr...

journal_title：Trends in cell biology

authors： Pettitt JM,van Driel IR,Toh BH,Gleeson PA

更新日期：1996-02-01 00:00:00

abstract：:How do the many different components of an organelle assemble into a functional structure at an appropriate place and time? Flagellar regeneration by the biflagellate green alga Chlamydomonas is one experimental system in which genetics, biochemistry and ultrastructural analysis are being combined to investigate the a...

journal_title：Trends in cell biology

authors： Johnson KA,Rosenbaum JL

更新日期：1993-05-01 00:00:00

abstract：:The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines po...

journal_title：Trends in cell biology

authors： Schubert D

更新日期：1992-03-01 00:00:00

abstract：:The morphological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently. A prerequisite for each origin of multicellularity was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in comp...

journal_title：Trends in cell biology

authors： Abedin M,King N

更新日期：2010-12-01 00:00:00

abstract：:Every heart beat is not equal. As physiological demands of the cardiovascular system change, cardiac myocytes modulate contractile parameters including the rate and force of contraction. Adaptive responses require the sensing of biomechanical signals involving the interface between the contractile cytoskeleton (myofib...

journal_title：Trends in cell biology

authors： Miller MK,Granzier H,Ehler E,Gregorio CC

更新日期：2004-03-01 00:00:00

abstract：:In vitro cell biology has become an effective way to identify molecules responsible for membrane traffic. We have used this approach to study the assembly and budding of coated pits. So far our system has allowed us to identify a high-affinity binding site for the AP2 subunit on the inside surface of plasma membranes,...

journal_title：Trends in cell biology

authors： Anderson RG

更新日期：1993-06-01 00:00:00

abstract：:The availability of green fluorescent protein (GFP) as a tracer for observing proteins in living cells has revolutionized cell biology and spurred an intensive search for GFP variants with novel characteristics, additional autofluorescent proteins and alternative techniques of protein labelling. Two recent studies - o...

journal_title：Trends in cell biology

authors： Falk M

更新日期：2002-09-01 00:00:00

abstract：:Damage to any tissue triggers a cascade of events that leads to rapid repair of the wound - if the tissue is skin, then repair involves re-epithelialization, formation of granulation tissue and contraction of underlying wound connective tissues. This concerted effort by the wounded cell layers is accompanied by, and m...

journal_title：Trends in cell biology

authors： Martin P,Leibovich SJ

更新日期：2005-11-01 00:00:00

abstract：:Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin br...

journal_title：Trends in cell biology

authors： Ly P,Cleveland DW

更新日期：2017-12-01 00:00:00

abstract：:Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...

journal_title：Trends in cell biology

authors： Ahmed K,Gerber DA,Cochet C

更新日期：2002-05-01 00:00:00

abstract：:Research performed over the past decade has transformed apoptosis from a distinctive form of cell death known only by its characteristic morphology and genomic destruction to an increasingly well understood cellular disassembly pathway remarkable for its complex and multifaceted regulation. Here, we summarize current ...

journal_title：Trends in cell biology

authors： Kaufmann SH,Hengartner MO

更新日期：2001-12-01 00:00:00

abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...

journal_title：Trends in cell biology

authors： Baas PW,Ahmad FJ

更新日期：2001-06-01 00:00:00

abstract：:Epithelial cells comprise the foundation for the majority of organs in the mammalian body, and are the source of approximately 90% of all human cancers. Characteristically, epithelial cells form intercellular adhesions, exhibit apical/basal polarity, and orient their mitotic spindles in the plane of the epithelial she...

journal_title：Trends in cell biology

authors： McCaffrey LM,Macara IG

更新日期：2011-12-01 00:00:00

abstract：:The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitri...

journal_title：Trends in cell biology

authors： van Deurs B,Roepstorff K,Hommelgaard AM,Sandvig K

更新日期：2003-02-01 00:00:00

abstract：:Chloroplasts have multiple suborganellar membranes. Correct and efficient translocation of chloroplast proteins from their site of synthesis into or across membranes to their functional compartments are fundamental processes. In recent years, several new components and regulatory mechanisms involved in chloroplast pro...

journal_title：Trends in cell biology

authors： Xu X,Ouyang M,Lu D,Zheng C,Zhang L

更新日期：2021-01-01 00:00:00

abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...

journal_title：Trends in cell biology

authors： Wilson EK

更新日期：2001-11-01 00:00:00

abstract：:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...

journal_title：Trends in cell biology

authors： Budi EH,Duan D,Derynck R

更新日期：2017-09-01 00:00:00

abstract：:Embryonic stem (ES) cells, like all cell types, are defined by their unique transcriptional signatures. The ability of ES cells to self-renew or exit the pluripotent state and enter differentiation requires extensive changes in their transcriptome and epigenome. Remarkably, transcriptional programs governing each cell...

journal_title：Trends in cell biology

authors： Fong YW,Cattoglio C,Yamaguchi T,Tjian R

更新日期：2012-06-01 00:00:00

abstract：:The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

journal_title：Trends in cell biology

authors： Wang F,Higgins JM

更新日期：2013-04-01 00:00:00

abstract：:Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epider...

journal_title：Trends in cell biology

authors： Vladar EK,Axelrod JD

更新日期：2008-11-01 00:00:00

abstract：:Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...

journal_title：Trends in cell biology

authors： Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JA

更新日期：2018-11-01 00:00:00

abstract：:Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...

journal_title：Trends in cell biology

authors： Otani T,Furuse M

更新日期：2020-10-01 00:00:00

abstract：:Chloroplasts depend on the nucleus for much of their proteome. Consequently, strong transcriptional coordination exists between the genomes, which is attuned to the developmental and physiological needs of the organelle. Recent studies highlight that the post-translational modifier ubiquitin adds another layer to plas...

journal_title：Trends in cell biology

authors： Hua Z,Vierstra RD

更新日期：2016-01-01 00:00:00

abstract：:Cellular myosin II is the principal motor responsible for cytokinesis. In higher eukaryotes, phosphorylation of the regulatory light chain (MLC) of myosin II is a primary means of activating myosin II and is known to be crucial for the execution of cell division. Because signals transmitted by the mitotic spindle coor...

journal_title：Trends in cell biology

authors： Matsumura F

更新日期：2005-07-01 00:00:00

abstract：:Many organisms stringently regulate the number, volume and enzymatic content of peroxisomes (and other organelles). Understanding this regulation requires knowledge of how organelles are assembled and selectively destroyed in response to metabolic cues. In the past decade, considerable progress has been achieved in th...

journal_title：Trends in cell biology

authors： Farré JC,Subramani S

更新日期：2004-09-01 00:00:00

abstract：:The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour and orchestrate functions of cells in tissue formation and homeostasis. The composition of the ECM, its three-dimensional organization and proteolytic remodelling are major determinants of the microenvironmental signalling context tha...

journal_title：Trends in cell biology

authors： Lukashev ME,Werb Z

更新日期：1998-11-01 00:00:00