Breaking glass?

abstract：:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...

journal_title：Trends in cell biology

authors： Dalal K,Duong F

更新日期：2011-09-01 00:00:00

abstract：:A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (T...

journal_title：Trends in cell biology

authors： Peset I,Vernos I

更新日期：2008-08-01 00:00:00

abstract：:Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in m...

journal_title：Trends in cell biology

authors： Clarke PR,Zhang C

更新日期：2001-09-01 00:00:00

abstract：:The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...

journal_title：Trends in cell biology

authors： Gardner RD,Burke DJ

更新日期：2000-04-01 00:00:00

abstract：:Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...

journal_title：Trends in cell biology

authors： Greenberg MJ,Ostap EM

更新日期：2013-02-01 00:00:00

abstract：:Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we re...

journal_title：Trends in cell biology

authors： Yan J,Horng T

更新日期：2020-12-01 00:00:00

abstract：:The nuclear envelope (NE) breaks down reversibly and reassembles at mitosis. Two models of mitotic nuclear membrane disassembly and reformation have emerged from studies of NE dynamics in somatic cells and egg extracts. One model suggests that nuclear membranes fragment reversibly by vesiculation, producing NE-derived...

journal_title：Trends in cell biology

authors： Collas P,Courvalin JC

更新日期：2000-01-01 00:00:00

abstract：:The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. ...

journal_title：Trends in cell biology

authors： Bamburg JR,McGough A,Ono S

更新日期：1999-09-01 00:00:00

abstract：:The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counte...

journal_title：Trends in cell biology

authors： Torraca V,Mostowy S

更新日期：2018-02-01 00:00:00

abstract：:Embryonic stem (ES) cells, like all cell types, are defined by their unique transcriptional signatures. The ability of ES cells to self-renew or exit the pluripotent state and enter differentiation requires extensive changes in their transcriptome and epigenome. Remarkably, transcriptional programs governing each cell...

journal_title：Trends in cell biology

authors： Fong YW,Cattoglio C,Yamaguchi T,Tjian R

更新日期：2012-06-01 00:00:00

abstract：:Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in th...

journal_title：Trends in cell biology

authors： Tornatore L,Thotakura AK,Bennett J,Moretti M,Franzoso G

更新日期：2012-11-01 00:00:00

abstract：:The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in each cell cycle. Regulation of the replication licensing system, which promotes the assembly of complexes of proteins termed Mcm2-7 onto replication origins, is responsible for preventing r...

journal_title：Trends in cell biology

authors： Blow JJ,Hodgson B

更新日期：2002-02-01 00:00:00

abstract：:Vascular barrier function is controlled at cell-cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms contro...

journal_title：Trends in cell biology

authors： Lagendijk AK,Yap AS,Hogan BM

更新日期：2018-03-01 00:00:00

abstract：:Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientifi...

journal_title：Trends in cell biology

authors： Slepchenko BM,Schaff JC,Macara I,Loew LM

更新日期：2003-11-01 00:00:00

abstract：:Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and other stresses. The core component proteins that regulate autophagy are well known, and the formation of a double-membrane structure that encompasses cytosolic car...

journal_title：Trends in cell biology

authors： McEwan DG,Dikic I

更新日期：2011-04-01 00:00:00

abstract：:During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

journal_title：Trends in cell biology

authors： Sonneveld S,Verhagen BMP,Tanenbaum ME

更新日期：2020-08-01 00:00:00

abstract：:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...

journal_title：Trends in cell biology

authors： Thelen AM,Zoncu R

更新日期：2017-11-01 00:00:00

abstract：:The morphological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently. A prerequisite for each origin of multicellularity was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in comp...

journal_title：Trends in cell biology

authors： Abedin M,King N

更新日期：2010-12-01 00:00:00

abstract：:The regulation of endothelial cell contacts is of central importance for the barrier function of the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity of endothelial cell contacts is regulated during angiogenesis by growth factors, such as vascular endothelial growth factor ...

journal_title：Trends in cell biology

authors： Vestweber D,Winderlich M,Cagna G,Nottebaum AF

更新日期：2009-01-01 00:00:00

abstract：:Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transforma...

journal_title：Trends in cell biology

authors： Bouchard C,Staller P,Eilers M

更新日期：1998-05-01 00:00:00

abstract：:When starved, the fission yeast Schizosaccharomyces pombe responds by producing mating factors or pheromones that signal to cells of the opposite sex to initiate mating. Like its distant relative Saccharomyces cerevisiae, cells of the two mating types of S. pombe each produce a distinct pheromone that binds to recepto...

journal_title：Trends in cell biology

authors： Nielsen O

更新日期：1993-02-01 00:00:00

abstract：:Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emp...

journal_title：Trends in cell biology

authors： Vallee RB,Seale GE,Tsai JW

更新日期：2009-07-01 00:00:00

abstract：:Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...

journal_title：Trends in cell biology

authors： van der Laan M,Bohnert M,Wiedemann N,Pfanner N

更新日期：2012-04-01 00:00:00

abstract：:Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunct...

journal_title：Trends in cell biology

authors： Slaats GG,Giles RH

更新日期：2015-06-01 00:00:00

abstract：:The ability of cells to utilize cholesterol derived from lipoprotein is important in plasma membrane biosynthesis, steroidogenesis and the regulation of sterol synthesis. While the endocytosis of lipoprotein-derived cholesterol has been well characterized, the subsequent events that mediate its post-lysosomal intracel...

journal_title：Trends in cell biology

authors： Evans RM

更新日期：1994-05-01 00:00:00

abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...

journal_title：Trends in cell biology

authors： Norton JD,Deed RW,Craggs G,Sablitzky F

更新日期：1998-02-01 00:00:00

abstract：:Nuclear proteins are transported from the cytoplasm into the nucleus via nuclear envelope pore complexes (NPCs). At the molecular level, the mechanisms responsible for this transport remain obscure. However, it is known that, for many proteins, the process requires ATP and proceeds against formidable nucleocytoplasmic...

journal_title：Trends in cell biology

authors： Paine PL

更新日期：1993-10-01 00:00:00

abstract：:During the past 15 years mass spectrometry (MS)-based analyses have become established as the method of choice for direct protein identification and measurement. Owing to the remarkable improvements in the sensitivity and resolution of MS instruments, this technology has revolutionised the opportunities available for ...

journal_title：Trends in cell biology

authors： Ahmad Y,Lamond AI

更新日期：2014-04-01 00:00:00

abstract：:Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone state. Despite this, UQ is also believed to be a membrane antioxidant. These properties place UQ at the center of hotly debated questions about how mi...

journal_title：Trends in cell biology

authors： Wang Y,Hekimi S

更新日期：2016-05-01 00:00:00

abstract：:Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now well established that signaling by integrins mediates many of these effects. Ten years of research has seen integrin signaling advance on many fronts towards a molecular understanding of the control mechanisms. Most strik...

journal_title：Trends in cell biology

authors： Schwartz MA

更新日期：2001-12-01 00:00:00