Abstract：
:Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone state. Despite this, UQ is also believed to be a membrane antioxidant. These properties place UQ at the center of hotly debated questions about how mitochondria and reactive oxygen species (ROS) impact aging and disease. New studies using transgenic mouse models have provided unexpected insights into whether, and how, UQ is required in various processes, cell types, and subcellular locations. These studies have not only shed light on the role of mitochondria and ROS in the aging process, but also question the mechanisms of action by which UQ might function as a therapeutic agent.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Wang Y,Hekimi Sdoi
10.1016/j.tcb.2015.12.007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
367-378issue
5eissn
0962-8924issn
1879-3088pii
S0962-8924(16)00003-9journal_volume
26pub_type
杂志文章,评审abstract：:Sphingomyelin used to be considered only as a structural molecule of the outer leaflet of the plasma membrane of mammalian cells. However, in the last five years it has become clear that sphingomyelin is rapidly degraded and resynthesized in a pathway that could function in signal transduction. Indeed, it is now known...
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更新日期：2014-09-01 00:00:00
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journal_title：Trends in cell biology
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