Abstract：
:A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminating in significant cell injury. Recently we showed that in the nematode, Caenorhabditis elegans, oxidation of K(+) channels by ROS is a major mechanism underlying the loss of neuronal function. The C. elegans results support an argument that K(+) channels controlling neuronal excitability and survival might provide a common, functionally important substrate for ROS in aging mammals. Here we discuss the implications that oxidation of K(+) channels by ROS might have for the mammalian brain during normal aging, as well as in neurodegenerative diseases such as Alzheimer's and Parkinson's. We argue that oxidation of K(+) channels by ROS is a common theme in the aging brain and suggest directions for future experimentation.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Sesti F,Liu S,Cai SQdoi
10.1016/j.tcb.2009.09.008subject
Has Abstractpub_date
2010-01-01 00:00:00pages
45-51issue
1eissn
0962-8924issn
1879-3088pii
S0962-8924(09)00227-Xjournal_volume
20pub_type
杂志文章,评审abstract：:Microbiology has a long way to go. Microbes are ubiquitous, and all other life forms in the biosphere exist solely because of them, but, as less than 1% of microorganisms can be grown in the laboratory, more than a century of research has revealed only the tip of the iceberg concerning this most crucial of life scienc...
journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2003-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.09.003
更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.07.003
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2009.10.003
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journal_title：Trends in cell biology
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