Abstract：
:The E2F family of transcriptional regulators sits at the center of cell cycle gene expression and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the retinoblastoma family of proteins is well established, much less is known about their regulation by ubiquitin pathways. Recent studies placed the Skp1-Cul1-F-box-protein (SCF) family of E3 ubiquitin ligases with the F-box protein Cyclin F at the center of E2F regulation, demonstrating temporal proteolysis of both activator and atypical repressor E2Fs. Importantly, these E2F members, in particular activator E2F1 and repressors E2F7 and E2F8, form a feedback circuit at the crossroads of cell cycle and cell death. Moreover, Cyclin F functions in a reciprocal circuit with the cell cycle E3 ligase anaphase-promoting complex/cyclosome (APC/C), which also controls E2F7 and E2F8. This review focuses on the complex contours of feedback within this circuit, highlighting the deep crosstalk between E2F, SCF-Cyclin F, and APC/C in regulating the oscillator underlying human cell cycles.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Emanuele MJ,Enrico TP,Mouery RD,Wasserman D,Nachum S,Tzur Adoi
10.1016/j.tcb.2020.05.002subject
Has Abstractpub_date
2020-08-01 00:00:00pages
640-652issue
8eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30099-4journal_volume
30pub_type
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