Metastasis Stemming from Circulating Tumor Cell Clusters.

Abstract:

:Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel insights into the epigenetic regulation of 'stemness' in CTC clusters.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Yu M

doi

10.1016/j.tcb.2019.02.001

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

275-276

issue

4

eissn

0962-8924

issn

1879-3088

pii

S0962-8924(19)30023-6

journal_volume

29

pub_type

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