Abstract：
:Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Bose S,Ramesh V,Locasale JWdoi
10.1016/j.tcb.2019.05.005subject
Has Abstractpub_date
2019-09-01 00:00:00pages
695-703issue
9eissn
0962-8924issn
1879-3088pii
S0962-8924(19)30084-4journal_volume
29pub_type
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