Abstract：
:DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic potential. Nevertheless, programmed DSBs (prDSBs) contribute to several biological processes. Formation of prDSBs is the 'price to pay' to achieve these essential biological functions. Generated by domesticated PiggyBac transposases, prDSBs have been integrated in the life cycle of ciliates. Created by Spo11 during meiotic recombination, they constitute a driving force of evolution and ensure balanced chromosome content for successful reproduction. Produced by the RAG1/2 recombinase, they are required for the development of the adaptive immune system in many species. The coevolution of processes that couple introduction of prDSBs to their accurate repair may constitute an effective safeguard against genomic instability.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Bétermier M,Borde V,de Villartay JPdoi
10.1016/j.tcb.2019.11.005subject
Has Abstractpub_date
2020-02-01 00:00:00pages
87-96issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(19)30201-6journal_volume
30pub_type
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