Abstract：
:Caveolae are ampullate (flask-shaped) invaginations that are abundant in the plasma membrane of many mammalian cell types. Although caveolae are implicated in a wide range of processes including endothelial transcytosis, lipid homeostasis and cellular signalling, a detailed molecular picture of many aspects of their function has been elusive. Until recently, the only extensively characterised protein components of caveolae were the caveolins. Recently, data from several laboratories have demonstrated that a family of four related proteins, termed cavins 1-4, plays key roles in caveolar biogenesis and function. Salient properties of the cavin family include their propensity to form complexes with each other and their different but overlapping tissue distribution. This review summarises recent data on the cavins, and sets them in the context of open questions on the construction and function of caveolae. The discovery of cavins implies that caveolae might have unexpectedly diverse structural properties, in accord with the wide range of functions attributed to these 'little caves'.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Hansen CG,Nichols BJdoi
10.1016/j.tcb.2010.01.005subject
Has Abstractpub_date
2010-04-01 00:00:00pages
177-86issue
4eissn
0962-8924issn
1879-3088pii
S0962-8924(10)00016-4journal_volume
20pub_type
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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pub_type： 评论,杂志文章
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pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2006.12.003
更新日期：2007-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.06.005
更新日期：2008-08-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2016.07.008
更新日期：2017-01-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2015.11.005
更新日期：2016-02-01 00:00:00
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