Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma.

abstract：:Recent work has revealed that mitochondria and chloroplasts are subject to direct control by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases are present at the outer membrane of both organelles where they mediate ubiquitination and turnover of other organellar proteins. Both organelles exhibit remarkable s...

journal_title：Trends in cell biology

authors： Ling Q,Jarvis P

更新日期：2013-08-01 00:00:00

abstract：:Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunct...

journal_title：Trends in cell biology

authors： Slaats GG,Giles RH

更新日期：2015-06-01 00:00:00

abstract：:Many organisms stringently regulate the number, volume and enzymatic content of peroxisomes (and other organelles). Understanding this regulation requires knowledge of how organelles are assembled and selectively destroyed in response to metabolic cues. In the past decade, considerable progress has been achieved in th...

journal_title：Trends in cell biology

authors： Farré JC,Subramani S

更新日期：2004-09-01 00:00:00

abstract：:Cell polarization requires the segregation of the plasma membrane into domains of distinct protein composition. The Lethal giant larvae (Lgl) protein of Drosophila, initially identified as a tumor suppressor, establishes such domains by localizing specific proteins to specific regions of the plasma membrane. However, ...

journal_title：Trends in cell biology

authors： Wirtz-Peitz F,Knoblich JA

更新日期：2006-05-01 00:00:00

abstract：:Cell biologists have used photobleaching to investigate the lateral mobility of fluorophores on the cell surface since the 1970s. Fusions of green fluorescent protein (GFP) to specific proteins extend photobleaching techniques to the investigation of protein dynamics within the cell, leading to renewed interest in pho...

journal_title：Trends in cell biology

authors： White J,Stelzer E

更新日期：1999-02-01 00:00:00

abstract：:The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylatio...

journal_title：Trends in cell biology

authors： Bard F,Chia J

更新日期：2016-05-01 00:00:00

abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...

journal_title：Trends in cell biology

authors： Baas PW,Ahmad FJ

更新日期：2001-06-01 00:00:00

abstract：:The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in each cell cycle. Regulation of the replication licensing system, which promotes the assembly of complexes of proteins termed Mcm2-7 onto replication origins, is responsible for preventing r...

journal_title：Trends in cell biology

authors： Blow JJ,Hodgson B

更新日期：2002-02-01 00:00:00

abstract：:The small vesicles shed from the surface of many cells upon stimulation, considered for a long time to be artefacts, are now recognized as specific structures that are distinct from the exosomes released upon exocytosis of multivesicular bodies. Recent reports indicate that shedding vesicles participate in important b...

journal_title：Trends in cell biology

authors： Cocucci E,Racchetti G,Meldolesi J

更新日期：2009-02-01 00:00:00

abstract：:Land plants have developed highly sophisticated intercellular channels called plasmodesmata (PD) that mediate the cell-to-cell trafficking of signaling molecules, including non-cell autonomous proteins (NCAPs) and RNAs. Until recently, the biological significance of this position-dependent intercellular signaling syst...

journal_title：Trends in cell biology

authors： Lucas WJ,Ham BK,Kim JY

更新日期：2009-10-01 00:00:00

abstract：:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...

journal_title：Trends in cell biology

authors： Thelen AM,Zoncu R

更新日期：2017-11-01 00:00:00

abstract：:The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regula...

journal_title：Trends in cell biology

authors： Kamenz J,Hauf S

更新日期：2017-01-01 00:00:00

abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...

journal_title：Trends in cell biology

authors： Norton JD,Deed RW,Craggs G,Sablitzky F

更新日期：1998-02-01 00:00:00

abstract：:The actomyosin cytoskeleton is responsible for most force-driven processes in cells and tissues. How it assembles into the necessary structures at the right time and place is an important question. Here, we focus on molecular mechanisms of actomyosin regulation recently elucidated in animal models, and highlight sever...

journal_title：Trends in cell biology

authors： Agarwal P,Zaidel-Bar R

更新日期：2019-02-01 00:00:00

abstract：:The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...

journal_title：Trends in cell biology

authors： Gardner RD,Burke DJ

更新日期：2000-04-01 00:00:00

abstract：:A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...

journal_title：Trends in cell biology

authors： Sesti F,Liu S,Cai SQ

更新日期：2010-01-01 00:00:00

abstract：:Members of the transforming growth factor-beta (TGF-beta) family play pivotal roles in development and disease. These cytokines elicit their pleiotropic effects on cells, including endothelial and mural cells, through specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription fa...

journal_title：Trends in cell biology

authors： Pardali E,Goumans MJ,ten Dijke P

更新日期：2010-09-01 00:00:00

abstract：:There is a pronounced tendency among cell biologists to focus on qualitative aspects of cell physiology. The remarkable accomplishments of evolution in creating cells can only be fully appreciated, however, by combining this qualitative analysis with a quantitative assessment of cellular constituents and processes. He...

journal_title：Trends in cell biology

authors： Yewdell JW

更新日期：2001-07-01 00:00:00

abstract：:A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule requir...

journal_title：Trends in cell biology

authors： Gallet A

更新日期：2011-04-01 00:00:00

abstract：:Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signallin...

journal_title：Trends in cell biology

authors： Ellis S,Mellor H

更新日期：2000-03-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:Embryonic stem (ES) cells, like all cell types, are defined by their unique transcriptional signatures. The ability of ES cells to self-renew or exit the pluripotent state and enter differentiation requires extensive changes in their transcriptome and epigenome. Remarkably, transcriptional programs governing each cell...

journal_title：Trends in cell biology

authors： Fong YW,Cattoglio C,Yamaguchi T,Tjian R

更新日期：2012-06-01 00:00:00

abstract：:Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely com...

journal_title：Trends in cell biology

authors： Choo KH

更新日期：2000-05-01 00:00:00

abstract：:Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientifi...

journal_title：Trends in cell biology

authors： Slepchenko BM,Schaff JC,Macara I,Loew LM

更新日期：2003-11-01 00:00:00

abstract：:Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan. Other chondrodystrophies are te...

journal_title：Trends in cell biology

authors： Vertel BM

更新日期：1995-12-01 00:00:00

abstract：:Accurate spindle positioning is crucial for spatial control of cell division. During metazoan development, coordination between polarity cues and spindle position also ensures correct segregation of cell fate determinants. Converging evidence indicates that spindle positioning is achieved through interactions between ...

journal_title：Trends in cell biology

authors： Gönczy P

更新日期：2002-07-01 00:00:00

abstract：:Long-distance cell-cell communication is essential for organ development and function. Whereas neurons communicate at long distances by transferring signals at sites of direct contact (i.e., at synapses), it has been presumed that the only way other cell types signal is by dispersing signals through extracellular flui...

journal_title：Trends in cell biology

authors： Kornberg TB,Roy S

更新日期：2014-06-01 00:00:00

abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...

journal_title：Trends in cell biology

authors： Wilson EK

更新日期：2001-11-01 00:00:00

abstract：:Two related transmembrane proteins in mammalian cells bind the mannose 6-phosphate recognition marker present on all soluble lysosomal hydrolases. Recent studies of cells that express only one or neither of these proteins have shed light not only on their function in directing lysosomal enzymes into the endocytic path...

journal_title：Trends in cell biology

authors： Ludwig T,Le Borgne R,Hoflack B

更新日期：1995-05-01 00:00:00

abstract：:Fluorescent proteins have revolutionized biomedical research as they are easy to use for protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging in various models. Current methods allow easy and quick integration of fluorescent markers to endogenous genes of interest. In this rev...

journal_title：Trends in cell biology

authors： Bukhari H,Müller T

更新日期：2019-11-01 00:00:00