Abstract：
:Members of the transforming growth factor-beta (TGF-beta) family play pivotal roles in development and disease. These cytokines elicit their pleiotropic effects on cells, including endothelial and mural cells, through specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. This review highlights recent progress in our understanding of TGF-beta signaling in vascular development and angiogenesis and of how perturbed TGF-beta signaling might contribute to vascular pathologies, tumor angiogenesis and tumor progression. Recent research has provided exciting insights into the role of the TGF-beta type I receptor (ALK1) in tumor angiogenesis and the curative effects of thalidomide on vascular malformations in hereditary hemorrhagic telangiectasia (HHT). These advances provide opportunities for the development of new therapies for diseases with vascular abnormalities.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Pardali E,Goumans MJ,ten Dijke Pdoi
10.1016/j.tcb.2010.06.006subject
Has Abstractpub_date
2010-09-01 00:00:00pages
556-67issue
9eissn
0962-8924issn
1879-3088pii
S0962-8924(10)00121-2journal_volume
20pub_type
杂志文章,评审abstract：:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...
journal_title：Trends in cell biology
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abstract：:The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signali...
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journal_title：Trends in cell biology
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doi：10.1016/j.tcb.2010.09.006
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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更新日期：2014-05-01 00:00:00
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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