Abstract：
:Diverse biological and developmental functions are mediated by signalling through the epidermal growth factor (EGF) receptor. In flies, many different mechanisms are used to control and restrict EGF-R signalling, including ligand processing, ligand variety (an inhibitor as well as activators), transcription and perhaps subcellular localization of the receptor. Since the components of EGF-R signalling have been well conserved, understanding these different modes of receptor regulation in flies should lead to general insights into the strategies of receptor activation.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Wasserman JD,Freeman Mdoi
10.1016/S0962-8924(97)01143-4subject
Has Abstractpub_date
1997-11-01 00:00:00pages
431-6issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(97)01143-4journal_volume
7pub_type
杂志文章abstract：:Understanding the basic mechanisms underlying chromatin dynamics during DNA replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction, chromatin organization represents a means to regulate genome function. Thus, the inheritance and maintenance of the DNA sequence, along with its organization ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.10.002
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abstract：:Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is generally understood that the oncogenic signaling pathways are overactivated, or at least abnormally activated, in cancer cells, important mechanistic details of such abnormal activation remain unresolved. Among these details are s...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.08.005
更新日期：2019-11-01 00:00:00
abstract：:Cellular organization of the cytoskeleton, assembly of intracellular signaling complexes and movement of membrane receptors into supramolecular activation complexes (SMACs) are crucial prerequisites for lymphocyte activation and function. Full T-cell activation requires costimulatory signals in addition to antigen-med...
journal_title：Trends in cell biology
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doi：10.1016/s0962-8924(01)01981-x
更新日期：2001-05-01 00:00:00
abstract：:Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand known functional capacities of microtubule (MT) polymers. One such innovation - the ventral disc - is a cup-shaped MT organelle that the parasite Giardia uses to attach to the small intestine of its host. The molecular mechanisms ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2017.10.007
更新日期：2018-02-01 00:00:00
abstract：:Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcripti...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.02.001
更新日期：2019-04-01 00:00:00
abstract：:A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.09.008
更新日期：2010-01-01 00:00:00
abstract：:Ras proteins regulate cell growth and differentiation, and their mutation plays a major, direct role in causing human cancer. For years, their precise function has been a mystery. One of the pathways Ras controls has recently been identified. It consists of a cascade of kinases (Raf, MEK and MAP kinases) that transmit...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(94)90075-2
更新日期：1994-10-01 00:00:00
abstract：:The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.08.005
更新日期：2020-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(99)01559-7
更新日期：1999-06-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.03.007
更新日期：2008-06-01 00:00:00
abstract：:Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2018.06.008
更新日期：2018-11-01 00:00:00
abstract：:A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule requir...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2010.12.005
更新日期：2011-04-01 00:00:00
abstract：:Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(01)02063-3
更新日期：2001-08-01 00:00:00
abstract：:The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent s...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2005.03.008
更新日期：2005-05-01 00:00:00
abstract：:Synaptic junctions are highly specialized structures designed to promote the rapid and efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane within the central nervous system. Proteins containing PDZ domains play a fundamental organizational role at both the pre- and postsynaptic...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(00)01783-9
更新日期：2000-07-01 00:00:00
abstract：:Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of t...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.12.001
更新日期：2020-02-01 00:00:00
abstract：:Microbiology and cell biology both involve the study of cells, albeit at different levels of complexity and scale. Interactions between both fields during the past 25 years have led to major conceptual and technological advances that have reshaped the whole biology landscape and its biomedical applications. ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2016.04.008
更新日期：2016-07-01 00:00:00
abstract：:The transport of protein through the secretory pathway of eukaryotic cells relies on small vesicular carriers, which mediate the movement of cargo between different compartments. Here, Meir Aridor and Bill Balch summarize what is currently known about the role of the cytosolic coat complexes in directing the formation...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(96)10027-1
更新日期：1996-08-01 00:00:00
abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(01)02005-0
更新日期：2001-06-01 00:00:00
abstract：:The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitri...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(02)00039-9
更新日期：2003-02-01 00:00:00
abstract：:Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well describe...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2006.12.003
更新日期：2007-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(94)90144-9
更新日期：1994-06-01 00:00:00
abstract：:Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.10.008
更新日期：2013-02-01 00:00:00
abstract：:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2011.04.005
更新日期：2011-09-01 00:00:00
abstract：:Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditi...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.08.008
更新日期：2020-12-01 00:00:00
abstract：:It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.10.006
更新日期：2013-02-01 00:00:00
abstract：:Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...
journal_title：Trends in cell biology
pub_type： 评论,杂志文章
doi：10.1016/j.tcb.2018.04.005
更新日期：2018-07-01 00:00:00
abstract：:A cell-free system that mimics mitotic fragmentation of Golgi stacks has provided a working model for the disassembly process. Two distinct pathways, one COP-dependent and one COP-independent, act on Golgi stacks to give rise to two types of end products: transport vesicles and larger, more heterogeneous vesicles and ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/s0962-8924(00)89094-7
更新日期：1995-11-01 00:00:00
abstract：:DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(98)01383-x
更新日期：1998-12-01 00:00:00
abstract：:Collective cell migration results from the establishment and maintenance of collective polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader-follower cell behavior and results in ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2015.06.003
更新日期：2015-09-01 00:00:00
