A New Paradigm in Catalase Research.

abstract：:Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discu...

journal_title：Trends in cell biology

authors： Wasserman S

更新日期：1998-03-01 00:00:00

abstract：:Membrane trafficking pathways function to sort and transport cargoes to various intracellular compartments and to the plasma membrane. This allows precise spatiotemporal control of processes such as signal transduction, which in turn is crucial for complex cell functions such as cell division, migration and polarity. ...

journal_title：Trends in cell biology

authors： Wickström SA,Fässler R

更新日期：2011-05-01 00:00:00

abstract：:The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...

journal_title：Trends in cell biology

authors： Storz P

更新日期：2007-01-01 00:00:00

abstract：:The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...

journal_title：Trends in cell biology

authors： Spencer WJ,Lewis TR,Pearring JN,Arshavsky VY

更新日期：2020-11-01 00:00:00

abstract：:Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...

journal_title：Trends in cell biology

authors： Otani T,Furuse M

更新日期：2020-10-01 00:00:00

abstract：:Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell c...

journal_title：Trends in cell biology

authors： Kirschner M

更新日期：1999-12-01 00:00:00

abstract：:It was once believed that common mechanisms underpin the transfer of proteins across the membrane systems of organelles such as mitochondria, chloroplasts and peroxisomes. Now that many of the core components of the translocases have been indentified, results discussed at a recent conference [Max-Delbrück-Centrum Symp...

journal_title：Trends in cell biology

authors： Kunau WH,Agne B,Girzalsky W

更新日期：2001-09-01 00:00:00

abstract：:How do the many different components of an organelle assemble into a functional structure at an appropriate place and time? Flagellar regeneration by the biflagellate green alga Chlamydomonas is one experimental system in which genetics, biochemistry and ultrastructural analysis are being combined to investigate the a...

journal_title：Trends in cell biology

authors： Johnson KA,Rosenbaum JL

更新日期：1993-05-01 00:00:00

abstract：:The role o f iron in cell division, cell death and human disease has recently gained increased attention. The best studied process for iron uptake into mammalian cells involves traps ferrin and its receptor. This review discusses evidence supporting the existence of other routes by which iron can enter mammalian cells...

journal_title：Trends in cell biology

authors： Jefferies WA,Gabathuler R,Rothenberger S,Food M,Kennard ML

更新日期：1996-06-01 00:00:00

abstract：:An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...

journal_title：Trends in cell biology

authors： Romanowski P,Madine MA

更新日期：1996-05-01 00:00:00

abstract：:Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditi...

journal_title：Trends in cell biology

authors： Kondadi AK,Anand R,Reichert AS

更新日期：2020-12-01 00:00:00

abstract：:The power of fluorescence microscopy to study cellular structures and macromolecular complexes spans a wide range of size scales, from studies of cell behavior and function in physiological 3D environments to understanding the molecular architecture of organelles. At each length scale, the challenge in 3D imaging is t...

journal_title：Trends in cell biology

authors： Fischer RS,Wu Y,Kanchanawong P,Shroff H,Waterman CM

更新日期：2011-12-01 00:00:00

abstract：:The endoplasmic reticulum (ER) contains a variety of specialized proteins that interact with secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi apparatus. These accessory proteins might induce and/or stabilize a conformation that is required for secretion competence or they m...

journal_title：Trends in cell biology

authors： Herrmann JM,Malkus P,Schekman R

更新日期：1999-01-01 00:00:00

abstract：:Intracellular bacteria including major pathogens live in the cytoplasm or in cytoplasmic vacuoles within their host cell. However, some can invade more unusual intracellular niches such as the eukaryotic nucleus. Phylogenetically diverse intranuclear bacteria have been discovered in various protist, arthropod, marine ...

journal_title：Trends in cell biology

authors： Schulz F,Horn M

更新日期：2015-06-01 00:00:00

abstract：:The molecular mechanisms underlying targeted deposition of new membrane at the advancing furrow of a dividing cell have long been intriguing to cell biologists. Three recent studies have made use of Drosophila cellularization to explore current questions in this field. These findings indicate that both the secretory p...

journal_title：Trends in cell biology

authors： Strickland LI,Burgess DR

更新日期：2004-03-01 00:00:00

abstract：:Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...

journal_title：Trends in cell biology

authors： Johannes L,Goud B

更新日期：1998-04-01 00:00:00

abstract：:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural ...

journal_title：Trends in cell biology

authors： Machamer CE

更新日期：2003-06-01 00:00:00

abstract：:Fluorescent proteins have revolutionized biomedical research as they are easy to use for protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging in various models. Current methods allow easy and quick integration of fluorescent markers to endogenous genes of interest. In this rev...

journal_title：Trends in cell biology

authors： Bukhari H,Müller T

更新日期：2019-11-01 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intra...

journal_title：Trends in cell biology

authors： Andrews NW

更新日期：1995-03-01 00:00:00

abstract：:The vast diversity of cellular types and behaviours is mainly the result of combinatorial interactions between a limited number of transcription factors and cellular signalling pathways whose activity is stringently controlled by developmental, cellular and extracellular cues. Studies of serum response factor (SRF) ha...

journal_title：Trends in cell biology

authors： Posern G,Treisman R

更新日期：2006-11-01 00:00:00

abstract：:The components of the bacterial division machinery assemble to form a dynamic ring at mid-cell that drives cytokinesis. The nature of most division proteins and their assembly pathway is known. Our knowledge about the biochemical activities and protein interactions of some key division elements, including those respon...

journal_title：Trends in cell biology

authors： Martos A,Jiménez M,Rivas G,Schwille P

更新日期：2012-12-01 00:00:00

abstract：:Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals...

journal_title：Trends in cell biology

authors： Driskell RR,Watt FM

更新日期：2015-02-01 00:00:00

abstract：:The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...

journal_title：Trends in cell biology

authors： Meldi L,Brickner JH

更新日期：2011-12-01 00:00:00

abstract：:The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membr...

journal_title：Trends in cell biology

authors： Pettitt JM,van Driel IR,Toh BH,Gleeson PA

更新日期：1996-02-01 00:00:00

abstract：:Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...

journal_title：Trends in cell biology

authors： Greenberg MJ,Ostap EM

更新日期：2013-02-01 00:00:00

abstract：:Vesicular transport of proteins and lipids between distinct subcellular compartments is directly responsible for generating and maintaining the structure of the organelles of the secretory and endocytic pathways in eukaryotic cells. Rapid advances in a variety of experimental systems have resulted in the identificatio...

journal_title：Trends in cell biology

authors： Sztul ES,Melançon P,Howell KE

更新日期：1992-12-01 00:00:00

abstract：:Many organisms stringently regulate the number, volume and enzymatic content of peroxisomes (and other organelles). Understanding this regulation requires knowledge of how organelles are assembled and selectively destroyed in response to metabolic cues. In the past decade, considerable progress has been achieved in th...

journal_title：Trends in cell biology

authors： Farré JC,Subramani S

更新日期：2004-09-01 00:00:00

abstract：:Plant seeds store nitrogen by accumulating storage proteins in protein bodies within various compartments of the endomembrane system. The prolamin storage proteins of some cereal species are normally retained and assembled into protein bodies within the ER. Yet, these proteins lack a C-terminal KDEL/HDEL signal, sugge...

journal_title：Trends in cell biology

authors： Galili G,Altschuler Y,Levanony H

更新日期：1993-12-01 00:00:00

abstract：:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

journal_title：Trends in cell biology

authors： Nicholson AL,Pasquinelli AE

更新日期：2019-03-01 00:00:00

abstract：:Export signal sequences target newly synthesized proteins to the endoplasmic reticulum of eukaryotic cells and the plasma membrane of bacteria. All signal sequences contain a hydrophobic core region, but, despite this, they show great variation in both overall length and amino acid sequence. Recently, it has become cl...

journal_title：Trends in cell biology

authors： Martoglio B,Dobberstein B

更新日期：1998-10-01 00:00:00