解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::An enzyme immunoassay (EIA) was developed in which nuclear extracts were bound to the wells of polystyrene microtiter plates. The presence of various antigens in the extracts could be detected using antiserum raised against HeLa cell nucleoli. Normal human cell extracts, coupled to Sepharose as a solid phase absorbent...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90171-3
更新日期:1981-05-01 00:00:00
abstract::Twenty C57BL/6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL/6 mice, tumour growth was significantly slower than in control mice until day 18....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90068-9
更新日期:1981-04-01 00:00:00
abstract::During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the fo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90052-5
更新日期:1981-03-01 00:00:00
abstract::Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90047-1
更新日期:1981-03-01 00:00:00
abstract::The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90116-6
更新日期:1981-01-01 00:00:00
abstract::We have developed an epithelial cell line derived from mouse liver which represents a spectrum of malignant progression. When inoculated into mice at low passage, the cells induced benign cysts; after extensive subcultures, the same line induced low grade adenocarcinomas. A variant of these cells with increased invasi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90102-0
更新日期:1980-12-01 00:00:00
abstract::Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg). After 1.5 years, the 14 control and 28 treated animals were killed for general autopsy. The incidence of tumor formation in the treated animals was 78.6% as compared to 0% for the control animals. All tumors (...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90131-7
更新日期:1980-11-01 00:00:00
abstract::N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90053-1
更新日期:1980-10-01 00:00:00
abstract::Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90044-0
更新日期:1980-10-01 00:00:00
abstract::The cancer chemotherapeutic drug, 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC, DTIC, NSC-45388), is metabolised in rats to a structurally related product which was detected by thin-layer chromatography. The novel metabolite has a lower mobility and a colour reaction that is indistinguishable from the pare...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90076-2
更新日期:1980-09-01 00:00:00
abstract::Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90079-8
更新日期:1980-09-01 00:00:00
abstract::The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90033-6
更新日期:1980-08-01 00:00:00
abstract::The tumor promoter, phorbol-12-myristate-13-acetate (PMA), elicited a significant increase in lysosomal membrane permeability, as measured by release of free beta-glucurnidase, in guinea pig and hamster isolated hepatic lysosomes in vitro. This response was antagonized by zinc sulfate; zinc compounds having previously...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90065-8
更新日期:1980-07-01 00:00:00
abstract::The possibility that lithium ions stimulate growth of mammary tumors in vivo has been suggested by their mitogenic action in vitro on normal and neoplastic mammary epithelium [8] and their clinical use as stimulators of neutrophil production in tumor-bearing patients treated with cytotoxic drugs [14,15]. Three experim...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90090-7
更新日期:1980-05-01 00:00:00
abstract::The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fol...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90085-3
更新日期:1980-05-01 00:00:00
abstract::The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90113-5
更新日期:1980-04-01 00:00:00
abstract::The carcinogenic effects of BHP in organ-cultured embryonic rat pancreas was demonstrated by both the transplacental route followed by organ culture and by direct addition on BHP to the culture medium. Both methods appeared efficient for in vitro induction of adenocarcinoma. The incidence of carcinoma was 70% by direc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90133-0
更新日期:1980-03-01 00:00:00
abstract::PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90151-2
更新日期:1980-02-01 00:00:00
abstract::Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90004-x
更新日期:1980-01-01 00:00:00
abstract::The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90007-7
更新日期:1979-12-01 00:00:00
abstract::Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90023-5
更新日期:1979-11-01 00:00:00
abstract::The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90027-2
更新日期:1979-11-01 00:00:00
abstract::Many of the polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene (B[a]P), benzanthracene (BA), 3-methylcholanthrene (3-MC)) are not only carcinogenic, but also induce AHH in human tissues. Recently, chrysene has been implicated as an etiologic determinant of chemical carcinogenesis. Here we describe the ability of c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80059-2
更新日期:1979-10-01 00:00:00
abstract::A RNA-dependent DNA polymerase (RTase) was purified from human osteosarcoma tissue by successive column chromatography of the microsomal fraction on DEAE-cellulose (DE-23 and DE-52) and phosphocellulose. The purified enzyme has a molecular weight of about 68,000, a pH optimum of 8.1, a Mg2+ optimum of 0.8 mM, Mn2+ opt...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80078-6
更新日期:1979-08-01 00:00:00
abstract::Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80103-2
更新日期:1979-07-01 00:00:00
abstract::Human mitogen-stimulated lymphocytes, cultured in the presence of amosite asbestos (AS), demonstrated a slight increase in aryl hydrocarbon hydroxylase (AHH) activity compared with non-induced (control) cultures (P = 0.005). A much greater increase in enzyme activity occurred following addition of the inducers benzant...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80113-5
更新日期:1979-07-01 00:00:00
abstract::The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80075-0
更新日期:1979-06-01 00:00:00
abstract::Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80090-7
更新日期:1979-05-01 00:00:00
abstract::Breast fluid which bathes the mammary ductal epithelium may contain tumorogenic components. In view of the number of tobacco components inhaled during smoking, it was of interest whether nicotine and its metabolites were present in this fluid. Fluid was obtained from the nipple from menstruating women who were smokers...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80042-7
更新日期:1979-04-01 00:00:00
abstract::The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80005-1
更新日期:1979-02-01 00:00:00
abstract::The effect of diethylstilbestrol propionate (DES; 1 mg/kg body wt. was studied in the female offspring of rats exposed subcutaneously on the 19th day of gestation. Examination of vaginal smears showed persistent estrus in adult rats treated prenatally with DES. Compensatory ovarian hypertrophy (COH) induced by hemicas...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80008-7
更新日期:1979-02-01 00:00:00
abstract::A hepatic mixed-function oxygenase system gave enhanced biphenyl 2-hydroxylation in the presence of known carcinogens in vitro and was therefore suggested as a convenient short-term assay for the detection of potentially dangerous compounds. However, the test did not yield the expected increase of biphenyl 2-hydroxyla...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80017-8
更新日期:1979-01-01 00:00:00
abstract::Ritalin (methylphenidate hydrochloride), Benzedrine (amphetamine sulfate), and Dexedrine (dextroamphetamine sulfate) were examined for oncogenicity using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. At the concentr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80061-5
更新日期:1978-12-01 00:00:00
abstract::Tocopherol, a well known tissue anti-oxidant, given before local X-ray irradiation of 2 transplantable rat tumours was previously found to increase significantly the effect of irradiation. In the present study tocopherol did not influence the development of tumour necroses during growth of a transplantable rat hepatom...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80037-8
更新日期:1978-10-01 00:00:00
abstract::Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80046-9
更新日期:1978-08-01 00:00:00
abstract::Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80050-0
更新日期:1978-08-01 00:00:00
abstract::Microsomes isolated from hyperplastic liver nodules and hepatomas, induced by DL-ethionine, exhibited a reduced cytochrome P-450 content and aminopyrine N-demethylase activity when compared to the organelles of control and surrounding non-nodular liver. Phenobarbital administration to rats caused an increase of micros...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80006-8
更新日期:1978-07-01 00:00:00
abstract::N-Nitrosodiethanolamine (NDE1A) was administered by gavage to male rats in single doses of 1000, 500 and 100 mg/kg body wt. More than 70% of a given dose was excreted unchanged in the urine, essentially within the first 24 h after exposure. This high excretion rate might explain the relatively low carcinogenic potenti...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)94512-3
更新日期:1978-04-01 00:00:00
abstract::Twenty-eight transparent chambers were inserted into the cheek pouches of hamsters and daily serial observations made of the changing vasculature of transplants of 2 varieties (A-Mel-4B32, ZGYP1) of amelanotic melanomas. The tumor A-Mel-4B32 grew at a rate which covered 50% of the viewing area in 3--4 days, while the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)93797-7
更新日期:1978-02-01 00:00:00
abstract::The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)93192-0
更新日期:1978-01-01 00:00:00