An in vitro model of pancreas carcinoma: N-nitroso-bis(2-hydroxypropyl)amine effects.

abstract：:Development of chemotherapy resistance remains a major obstacle for glioma management. Exosome-mediated transfer of circular RNAs (circRNAs) are being found to have relevance to many human cancers, including glioma. The purpose of this study is to explore the effect and underlying mechanism of exosomal circRNA nuclear...

journal_title：Cancer letters

authors： Ding C,Yi X,Wu X,Bu X,Wang D,Wu Z,Zhang G,Gu J,Kang D

更新日期：2020-06-01 00:00:00

abstract：:KMT2A rearranged (KMT2Ar) acute lymphoblastic leukaemia (ALL) is a high-risk genomic subtype, with long-term survival rates of less than 60% across all age groups. These cases present a complex clinical challenge, with a high incidence in infants, high-risk clinical features and propensity for aggressive relapse. KMT2...

journal_title：Cancer letters

authors： Forgione MO,McClure BJ,Eadie LN,Yeung DT,White DL

更新日期：2020-01-28 00:00:00

abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...

journal_title：Cancer letters

authors： Thieu K,Ruiz ME,Owens DM

更新日期：2013-09-10 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main asp...

journal_title：Cancer letters

authors： Tang B,Hsu PY,Huang TH,Jin VX

更新日期：2013-11-01 00:00:00

abstract：:In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

journal_title：Cancer letters

authors： Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

更新日期：1995-05-04 00:00:00

abstract：:Alteration of the p16 tumor suppressor gene has been implicated as a critical lesion in the molecular pathogenesis of esophageal adenocarcinoma. The aim of this study was to characterize the spectrum of p16 alterations in surgically resected esophageal tissues, comprising histologically normal esophageal squamous and ...

journal_title：Cancer letters

authors： Hardie LJ,Darnton SJ,Wallis YL,Chauhan A,Hainaut P,Wild CP,Casson AG

更新日期：2005-01-20 00:00:00

abstract：:The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...

journal_title：Cancer letters

authors： Zhou A,Tang L,Zeng S,Lei Y,Yang S,Tang B

更新日期：2020-04-01 00:00:00

abstract：:Tumor acidity is now considered an important determinant of drug-resistance and tumor progression, and anti-acidic approaches, such as Proton Pump inhibitors (PPIs), have demonstrated promising antitumor and chemo-sensitizing efficacy. The main purpose of the present study was to evaluate the possible PPI-induced sens...

journal_title：Cancer letters

authors： Azzarito T,Venturi G,Cesolini A,Fais S

更新日期：2015-01-28 00:00:00

abstract：:The heat shock protein 40kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions ...

journal_title：Cancer letters

authors： Sterrenberg JN,Blatch GL,Edkins AL

更新日期：2011-12-22 00:00:00

abstract：:Aberrant expression of many long non-coding RNAs has been observed in various types of cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging knowledge with regard to the critical physiological and pathological roles of long non-coding RNAs in cancers makes them potential targets in ...

journal_title：Cancer letters

authors： Chen L,Dzakah EE,Shan G

更新日期：2018-04-01 00:00:00

abstract：:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...

journal_title：Cancer letters

authors： Denda A,Tsutsumi M,Tsujiuchi T,Eimoto H,Konishi Y,Sato S

更新日期：1989-04-01 00:00:00

abstract：:The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival wer...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V

更新日期：1996-12-20 00:00:00

abstract：:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In this paper, we report the comprehensive LOH analyses with microsatellite markers and their results at chromosome 8p11.1-q13.3 in gastric cancer. The microsatellite markers D8S2323 and D8S2330 exhibited high LOH frequencies, 54.2 and 57.1%, respect...

journal_title：Cancer letters

authors： Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

更新日期：2004-09-15 00:00:00

abstract：:We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...

journal_title：Cancer letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-10-01 00:00:00

abstract：:Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research communi...

journal_title：Cancer letters

authors： Sayin VI,Papagiannakopoulos T

更新日期：2017-02-28 00:00:00

abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

journal_title：Cancer letters

authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

更新日期：1997-12-09 00:00:00

abstract：:Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in vivo. The nuclear factor-kappa B (NF-kappaB) plays an important role in tumor cell growth, proliferation, invasion, and survival. In this study, we investigated the effects and the molecular mechanisms of gossypol on NF-kappaB ...

journal_title：Cancer letters

authors： Moon DO,Kim MO,Lee JD,Kim GY

更新日期：2008-06-18 00:00:00

abstract：:The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...

journal_title：Cancer letters

authors： Wallén-Ohman M,Lönnbro P,Schön A,Borrebaeck CA

更新日期：1993-12-10 00:00:00

abstract：:Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characterized human serine protease granzyme B has already been used as a the...

journal_title：Cancer letters

authors： Niesen J,Hehmann-Titt G,Woitok M,Fendel R,Barth S,Fischer R,Stein C

更新日期：2016-05-01 00:00:00

abstract：:Cyclin A is an S and G2/M phase regulatory protein and associates with Skp 2 in many transformed cells. Our previous results showed that 12 (39%) and 17 (55%) out of 31 hepatocellular carcinoma (HCC) patients exhibited higher protein expression levels of cyclin A and Skp 2, respectively, in their tumorous compared to ...

journal_title：Cancer letters

authors： Chao Y,Shih YL,Chen HJ,Lee SD,Huang TS

更新日期：1999-05-03 00:00:00

abstract：:Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DNA repair genes. This includes biallelic germ-line mutations in the MUTYH gene, encoding a DNA glycosylase that is involved...

journal_title：Cancer letters

authors： Paz-Elizur T,Sevilya Z,Leitner-Dagan Y,Elinger D,Roisman LC,Livneh Z

更新日期：2008-07-18 00:00:00

abstract：:Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

journal_title：Cancer letters

authors： Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

更新日期：1994-02-28 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to be linear in viral particles but EBV circularizes into an episomal form after infection. Recently, the presence of integrated EBV DNA has been reported. We investigated EBV integration into the human genome in EBV-associated disease using Southern blotting. One hundred four cases i...

journal_title：Cancer letters

authors： Ohshima K,Suzumiya J,Kanda M,Kato A,Kikuchi M

更新日期：1998-01-09 00:00:00

abstract：:The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to "reactive resistance" to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for ...

journal_title：Cancer letters

authors： Li Y,Cai B,Shen L,Dong Y,Lu Q,Sun S,Liu S,Ma S,Ma PX,Chen J

更新日期：2017-07-01 00:00:00

abstract：:The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...

journal_title：Cancer letters

authors： Keyler D,Pentel PR,Kuehl G,Collins G,Murphy SE

更新日期：2003-12-08 00:00:00

abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...

journal_title：Cancer letters

authors： Stika J,Vondrácek J,Hofmanová J,Simek V,Kozubík A

更新日期：2006-06-18 00:00:00

abstract：:Co-transfer of immunomodulatory and antiproliferative genes may be the basis for new strategies to potentiate tumor regression. In this study, we evaluated the in vitro effect of the introduction of human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes via recombinant adenoviru...

journal_title：Cancer letters

authors： Qiu ZH,Wu CT,Lao MF,Pan LZ,Li YM

更新日期：2002-08-28 00:00:00

abstract：:The kinase insert domain-containing receptor (KDR) is the human vascular endothelial growth factor (VEGF) receptor responsible for the mitogenic and angiogenic effects of VEGF. There is much experimental evidence to suggest that the VEGF/KDR pathway plays an important role in tumor angiogenesis, a process essential fo...

journal_title：Cancer letters

authors： Zhu Z,Lu D,Kotanides H,Santiago A,Jimenez X,Simcox T,Hicklin DJ,Bohlen P,Witte L

更新日期：1999-03-01 00:00:00

abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...

journal_title：Cancer letters

authors： Wajant H,Gerspach J,Pfizenmaier K

更新日期：2013-05-28 00:00:00