Abstract：
:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was observed with all the doses of 1-NP (1000, 500, 250 and 100 mg/kg body wt) used in the present experiment after 6 repeated intragastric (i.g.) intubations when accompanied by partial hepatectomy (PH) performed midway, but not after a single i.g. 1000 mg/kg body wt intubation plus PH. The potential for induction of foci by 1-NP, however, was far less than that by benzo[a]pyrene (B[a]P). The results thus suggested a weak but substantial initiation activity for 1-NP in the rat liver when given orally, particularly with repeated doses.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Denda A,Tsutsumi M,Tsujiuchi T,Eimoto H,Konishi Y,Sato Sdoi
10.1016/0304-3835(89)90031-1subject
Has Abstractpub_date
1989-04-01 00:00:00pages
21-6issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(89)90031-1journal_volume
45pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Patients with Her2-positive breast cancer exhibit de novo resistance or develop acquired resistance in less than one year after Her2 targeting treatment, but the mechanism is not fully elucidated. Compensatory pathways such as the IGF-1R/IRS-1 pathway, are activated, leading to aberrant enhanced PI3K/Akt/mTOR pathway ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.08.008
更新日期：2019-11-01 00:00:00
abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.025
更新日期：2020-10-28 00:00:00
abstract：:Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.05.027
更新日期：2016-08-28 00:00:00
abstract：:Eight chlorinated ethanes and 3 chlorinated ethylenes were tested in the BALB/c-3T3 cell transformation assay. Under the conditions of the assay, vinyl chloride and 1,1,1-trichloroethane induced a clear positive transformation response while 1,1,2-trichloroethane and trichloroethylene were weakly positive. Chloroethan...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90096-5
更新日期：1985-08-01 00:00:00
abstract：:Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00378-x
更新日期：2000-03-13 00:00:00
abstract：:Far-infrared (FIR) radiation is known to lessen the risk of angiogenesis-related diseases including cancer. Because deficiency of secretory clusterin (sCLU) has been reported to inhibit angiogenesis of endothelial cells (EC), we investigated using human umbilical vein EC (HUVEC) whether sCLU mediates the inhibitory ef...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.12.011
更新日期：2014-04-28 00:00:00
abstract：:Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.09.028
更新日期：2021-01-01 00:00:00
abstract：:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04621-1
更新日期：1997-03-19 00:00:00
abstract：:The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00477-1
更新日期：1998-02-27 00:00:00
abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.03.047
更新日期：2019-07-01 00:00:00
abstract：:Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.01.012
更新日期：2009-06-18 00:00:00
abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.04.028
更新日期：2018-08-01 00:00:00
abstract：:Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.09.020
更新日期：2017-01-01 00:00:00
abstract：:The scope of the structure-anticancer activity relationship among various aliphatic and aromatic hydrazones containing the N,N,N',N'-bis(1,2-ethanediyl)-phosphoric diamide moiety was studied. A total of 19 compounds were tested in vivo, using murine lymphocytic leukemia P388. At optimum dose all these compounds were a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90142-9
更新日期：1985-12-01 00:00:00
abstract：:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03836-l
更新日期：1995-07-20 00:00:00
abstract：:Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90080-s
更新日期：1993-06-15 00:00:00
abstract：:Oxaliplatin (trans-l-1,2-diaminocyclohexane oxalato Pt(II); 1R,2R-dach, l-OHP), its trans-d isomer (1S,2S-dach) and cis-dach (1R,2S-dach) isomers were compared in in vitro testing against human ovarian carcinoma cell lines A2780, A2780/CP (cisplatin resistant), A2780/l-OHP (oxaliplatin resistant), colon carcinoma cell...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03974-2
更新日期：1995-11-06 00:00:00
abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.01.006
更新日期：2019-04-10 00:00:00
abstract：:We have developed an epithelial cell line derived from mouse liver which represents a spectrum of malignant progression. When inoculated into mice at low passage, the cells induced benign cysts; after extensive subcultures, the same line induced low grade adenocarcinomas. A variant of these cells with increased invasi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90102-0
更新日期：1980-12-01 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in Southern China and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor prognosis. The emergence of single-cell sequencing represents a powerful tool to resolve tumor heterogeneity and delineate the complex communicat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.02.010
更新日期：2020-05-01 00:00:00
abstract：:The accumulation of benzoporphyrin derivative (BPD) in malignant and host cell populations of the mouse RIF tumor was studied by flow cytometry analysis of cells dissociated from the tumor tissue. The highest cellular BPD levels were found in a subpopulation of tumor associated macrophages (TAMs) characterized by a hi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03985-6
更新日期：1995-11-06 00:00:00
abstract：:The number of Krebs II tumour cells recovered from the ascitic fluid of mice fed for 8 days on a lactalbumin (La) control diet was about three times higher than that in animals fed a phytohaemagglutinin-containing (PHA) diet. Feeding a PHA diet for less than 8 days after tumour cell injection also led to a reduction i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00316-9
更新日期：1997-12-16 00:00:00
abstract：:Sonodynamic therapy (SDT) is a form of ultrasound therapy that has been shown to preferentially damage malignant cells based on the relatively enlarged size and altered cytology of neoplastic cells in comparison to normal cells. This study sought to determine whether cytoskeletal-directed agents that either disrupt (c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.02.001
更新日期：2015-05-01 00:00:00
abstract：:The expression of matrix metalloproteinases (MMPs) has been found to be positively correlated to the degree of malignancy in gliomas, indicating that poorly differentiated brain tumor cells produce more MMPs than differentiated ones. We determined the production of active MMP-2 in five glial (U138MG, U373MG, A172, C6,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00354-7
更新日期：2000-02-28 00:00:00
abstract：:Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG ind...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.09.020
更新日期：2009-02-18 00:00:00
abstract：:CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD13...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.09.009
更新日期：2018-12-01 00:00:00
abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.07.009
更新日期：2016-10-01 00:00:00
abstract：:We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90323-9
更新日期：1994-08-15 00:00:00
abstract：:The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90249-2
更新日期：1988-09-01 00:00:00
abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2012.05.008
更新日期：2013-09-10 00:00:00
