当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Intracellular levels of polyamines in Krebs II lymphosarcoma cells in mice fed phytohaemagglutinin-containing diets are coupled with altered tumour growth.

Intracellular levels of polyamines in Krebs II lymphosarcoma cells in mice fed phytohaemagglutinin-containing diets are coupled with altered tumour growth.

Abstract：

:The number of Krebs II tumour cells recovered from the ascitic fluid of mice fed for 8 days on a lactalbumin (La) control diet was about three times higher than that in animals fed a phytohaemagglutinin-containing (PHA) diet. Feeding a PHA diet for less than 8 days after tumour cell injection also led to a reduction in tumour cell growth. There was an apparent inverse relationship between the total tumour cell count and the intracellular content of putrescine, spermidine and spermine. Hyperplasia of the small intestine occurred in the mice during the development of the ascites. A series of other organs were not affected in the same manner. The results indicate that the polyamine content of Krebs II ascites cells must increase by more than three-fold in order to achieve the intracellular concentration necessary to be able to enter the S-phase. A partial synchronization of the tumour cell population is suggested. Hyperplastic growth of the small intestine would appear to compete with tumour cells for polyamines from a common body pool.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Bardocz S,Grant G,Duguid TJ,Brown DS,Pusztai A,Pryme IF

doi

10.1016/s0304-3835(97)00316-9

subject

Has Abstract

pub_date

1997-12-16 00:00:00

pages

25-9

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(97)00316-9

journal_volume

121

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Genetic networks responsive to low-intensity pulsed ultrasound in human lymphoma U937 cells.

    abstract：:To clarify the detailed molecular mechanism underlying cellular responses to nonthermal low-intensity pulsed ultrasound (LIPUS), gene expression patterns and genetic networks in human lymphoma U937 cells were examined using global-scale microarrays and computational gene expression analysis tools. Six hours after LIPU...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.05.018

    authors： Tabuchi Y,Takasaki I,Zhao QL,Wada S,Hori T,Feril LB Jr,Tachibana K,Nomura T,Kondo T

    更新日期：2008-11-08 00:00:00

  • p53 Codon 72 polymorphism and urothelial cancer risk.

    abstract：:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00518-9

    authors： Kuroda Y,Tsukino H,Nakao H,Imai H,Katoh T

    更新日期：2003-01-10 00:00:00

  • Caveolins in the development and diseases of musculoskeletal system.

    abstract：:Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.02.016

    authors： Serra M,Scotlandi K

    更新日期：2009-11-01 00:00:00

  • BZML, a novel colchicine binding site inhibitor, overcomes multidrug resistance in A549/Taxol cells by inhibiting P-gp function and inducing mitotic catastrophe.

    abstract：:Multidrug resistance (MDR) interferes with the efficiency of chemotherapy. Therefore, developing novel anti-cancer agents that can overcome MDR is necessary. Here, we screened a series of colchicine binding site inhibitors (CBSIs) and found that 5-(3, 4, 5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) displa...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.05.016

    authors： Bai Z,Gao M,Zhang H,Guan Q,Xu J,Li Y,Qi H,Li Z,Zuo D,Zhang W,Wu Y

    更新日期：2017-08-28 00:00:00

  • Chemopreventative activity of crude hydroxymatairesinol (HMR) extract in Apc(Min) mice [corrected].

    abstract：:We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly l...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00543-7

    authors： Oikannen SI,Pajari AM,Mutanen M

    更新日期：2000-10-31 00:00:00

  • Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152.

    abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lnc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.12.051

    authors： Yao Y,Ma J,Xue Y,Wang P,Li Z,Liu J,Chen L,Xi Z,Teng H,Wang Z,Li Z,Liu Y

    更新日期：2015-04-01 00:00:00

  • Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway.

    abstract：:The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.06.034

    authors： Chan KK,Leung CO,Wong CC,Ho DW,Chok KS,Lai CL,Ng IO,Lo RC

    更新日期：2017-09-10 00:00:00

  • Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation.

    abstract：:Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.04.040

    authors： Huang A,Ju HQ,Liu K,Zhan G,Liu D,Wen S,Garcia-Manero G,Huang P,Hu Y

    更新日期：2016-07-28 00:00:00

  • Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer.

    abstract：:Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this review, we will focus on T cell exhaustion as a phe...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2016.02.057

    authors： Bauer C,Kühnemuth B,Duewell P,Ormanns S,Gress T,Schnurr M

    更新日期：2016-10-10 00:00:00

  • Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat.

    abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.03.029

    authors： Fujita K,Matsuda E,Sekine K,Iigo M,Tsuda H

    更新日期：2004-09-15 00:00:00

  • Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo.

    abstract：:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.11.039

    authors： Wang YP,Yan J,Beger RD,Fu PP,Chou MW

    更新日期：2005-08-08 00:00:00

  • Matricellular proteins at the crossroad of inflammation and cancer.

    abstract：:Some proteins of the extracellular matrix known as matricellular proteins have regulatory function in all aspects of physiological and pathological stroma rearrangement. Many aspects of their activity are related to inflammation and immune response suggesting their role in bridging inflammation and cancer. ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2008.03.027

    authors： Sangaletti S,Colombo MP

    更新日期：2008-08-28 00:00:00

  • Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.

    abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.10.018

    authors： Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

    更新日期：2008-02-18 00:00:00

  • Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer.

    abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.01.026

    authors： Fu S,Chen X,Lo HW,Lin J

    更新日期：2019-04-28 00:00:00

  • Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

    abstract：:EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.01.003

    authors： Zhang L,Peng S,Dai X,Gan W,Nie X,Wei W,Hu G,Guo J

    更新日期：2017-04-01 00:00:00

  • High expression rate of Tn antigen in metastatic lesions of uterine cervical cancers.

    abstract：:The significance of altered expression of MN blood group antigens was examined by studies on the expressions of Thomsen-Friedenreich antigen (T antigen) and Tn antigen in primary and metastatic lesions of 29 human uterine cervical cancers. These antigens were measured by the avidin-biotin-peroxidase (ABC) method with ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90239-6

    authors： Hamada S,Furumoto H,Kamada M,Hirao T,Aono T

    更新日期：1993-11-01 00:00:00

  • Induction of 8-azaguanine or ouabain resistant somatic mutation of Chinese hamster lung cells by treatment with tryptophan products.

    abstract：:The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fol...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90085-3

    authors： Inui N,Nishi Y,Hasegawa MM,Kawachi T

    更新日期：1980-05-01 00:00:00

  • 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor.

    abstract：:Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.11.008

    authors： Lee SJ,Lee HM,Ji ST,Lee SR,Mar W,Gho YS

    更新日期：2004-05-10 00:00:00

  • SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.

    abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.05.014

    authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

    更新日期：2014-08-28 00:00:00

  • Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR).

    abstract：:Evidence is growing that low folate status may be a factor in the aetiology of several cancers, including breast cancer. The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic. We report a case-control study of two functional polymorphisms in MTHFR, dietary fola...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00030-7

    authors： Sharp L,Little J,Schofield AC,Pavlidou E,Cotton SC,Miedzybrodzka Z,Baird JO,Haites NE,Heys SD,Grubb DA

    更新日期：2002-07-08 00:00:00

  • A recombinant cell-permeable p53 fusion protein is selectively stabilized under hypoxia and inhibits tumor cell growth.

    abstract：:More than 50% of human tumors contain a mutation in p53. Over 90% of tumors are solid tumors. Solid tumors have low oxygenated regions, called hypoxic regions where the tumor cells are more resistant to radio- and chemo-therapy than their well-oxygenated counterparts. In this study, we constructed a cell-permeable p53...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.01.030

    authors： Yu Z,Wu J,Wu S,Jia P,Tong Y,Wu X,Wang Y

    更新日期：2009-06-28 00:00:00

  • Levels of myc, fos, Ha-ras, met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform.

    abstract：:Chloroform is a liver carcinogen in mice and a kidney carcinogen in rats. It is thought to act through a non-genotoxic-cytotoxic mode of action. Changes in expression of growth control genes accompanying chloroform-induced cytolethality and regeneration may play a part in the development of chloroform-induced tumors. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04123-7

    authors： Sprankle CS,Larson JL,Goldsworthy SM,Butterworth BE

    更新日期：1996-03-19 00:00:00

  • Interactions of antitumor drug ditercalinium with nucleic acids in solutions and in situ.

    abstract：:Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4',6-diamidino-2-pheny...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90303-5

    authors： Kapuscinski J,Traganos F,Darzynkiewicz Z

    更新日期：1988-11-01 00:00:00

  • N-nitrosation and N-nitration of morpholine by nitrogen dioxide: inhibition by ascorbate, glutathione and alpha-tocopherol.

    abstract：:Ascorbate anion and glutathione were found to inhibit the aqueous reaction between nitrogen dioxide (NO2) and morpholine (MOR) and thereby prevented the formation of N-nitrosomorpholine (NMOR) and N-nitromorpholine (NTMOR) at both pH 7.4 and 12.5. These antioxidants are approximately 3 orders of magnitude more reactiv...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90042-x

    authors： Cooney RV,Ross PD,Bartolini GL

    更新日期：1986-07-01 00:00:00

  • The timing of insulin/c-Ras signal is critical for its effect upon the differentiation of C3H10T1/2-derived preadipocytes.

    abstract：:The effect of the peptide hormone insulin upon the differentiation of a 10T1/2-derived preadipocytic line was found to display a potent time-dependence. Insulin addition before cell confluence strongly enhanced differentiation, while addition after confluence had no effect. In keeping with the role of c-Ras as a downs...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)04724-1

    authors： Preston T,Brownell H,Raptis L

    更新日期：1997-05-19 00:00:00

  • Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer.

    abstract：:Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.01.012

    authors： Ulybina YM,Kuligina ES,Mitiushkina NV,Rozanov ME,Ivantsov AO,Ponomariova DN,Togo AV,Levchenko EV,Shutkin VA,Brenister SI,Devilee P,Zhivotovsky B,Hirvonen A,Imyanitov EN

    更新日期：2009-06-18 00:00:00

  • Glutathione S-transferase-placental form expression and proliferation of hepatocytes in fumonisin B1-treated male and female Sprague-Dawley rats.

    abstract：:Fumonisin B1 (FB1), a mycotoxin produced by a common corn contaminant Fusarium moniliforme and a hepatocarcinogen in rats, has been previously suggested to act as a poor initiator, but a better promoter of gamma-glutamyltranspeptidase (GGT)-positive rat liver preneoplastic lesions. Using glutathione S-transferase-plac...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00046-9

    authors： Mehta R,Lok E,Rowsell PR,Miller JD,Suzuki CA,Bondy GS

    更新日期：1998-06-05 00:00:00

  • The carcinogenic effect of butylated hydroxyanisole on the stratified epithelium of the stomach in rat versus pig.

    abstract：:Butylated hydroxyanisole (BHA) was given to pregnant SPF pigs (Danish Landrace) in doses of 0, 50, 200 and 400 mg/kg body wt per day for 110 days. BHA was mixed in the diet (pelleted). Hyperkeratotic and parakeratotic proliferative changes of the stratified epithelium of the stomach were found at various degree in bot...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90090-3

    authors： Olsen P

    更新日期：1983-11-01 00:00:00

  • MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53.

    abstract：:The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovered that the NFAT1 tr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.114429

    authors： Wang W,Cheng JW,Qin JJ,Hu B,Li X,Nijampatnam B,Velu SE,Fan J,Yang XR,Zhang R

    更新日期：2019-09-10 00:00:00

  • Metabolic adaptation in hypoxia and cancer.

    abstract：:The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.12.020

    authors： Paredes F,Williams HC,San Martin A

    更新日期：2021-01-11 00:00:00