Abstract:
:The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fold higher mutagenicity than DEN when mutants were selected with ouabain. From these findings, it is suggested that pyrolyzates of amino acids may have mutagenic actions on somatic cells of animals, as well as carcinogenic actions.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Inui N,Nishi Y,Hasegawa MM,Kawachi Tdoi
10.1016/0304-3835(80)90085-3subject
Has Abstractpub_date
1980-05-01 00:00:00pages
185-9issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(80)90085-3journal_volume
9pub_type
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