Abstract:
:Pretreatment of EMT-6 murine tumor cells for 24 h with 10(-4) M 8-methoxypsoralen (8-MOP) increased the photocytotoxicity of Photofrin II (P2) after cell exposure to low doses (1-1.5 J/cm2) of UVA by two- to three-fold. 8-MOP alone had no cytotoxic action under these experimental conditions and did not significantly change the amount of P2 recovered in cells. 8-MOP enhanced the lipid peroxidation end product formation measured as thiobarbituric acid reactive substances (TBARS) during cell photosensitization by P2. The psoralen alone also slightly increased the TBARS level after UVA exposure. These results suggest that 8-MOP, albeit non-photocytotoxic by itself under our experimental conditions, could enhance the efficiency of P2 by increasing cellular lipid peroxidation following light exposure.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sousa C,Mazière C,Melo TS,Vincent-Fiquet O,Rogez JC,Santus R,Mazière JCdoi
10.1016/s0304-3835(98)00069-xsubject
Has Abstractpub_date
1998-06-19 00:00:00pages
177-82issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00069-Xjournal_volume
128pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90160-j
更新日期:1991-05-24 00:00:00
abstract::The stability of P-glycoprotein expression by high and low expressing cells obtained by flow sorting from two cell lines established from colonic tumors was assessed. Low expressing cells rapidly recovered expression to a level that was comparable to that determined for uncloned cells. High expressing cells maintained...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03838-n
更新日期:1995-08-01 00:00:00
abstract::It is known that the ingestion of cooked meat which contains carcinogenic heterocyclic amines causes increase in urinary mutagenicity in humans. Using 6 healthy non-smokers, we examined the effect of 3-week oral administration of Lactobacillus casei (bacilli commonly present in yoghurt), on the urinary mutagenicity de...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90261-7
更新日期:1993-09-30 00:00:00
abstract::The retinoblastoma (Rb) gene is associated with the pathogenesis of several types of human cancer, including retinoblastoma, osteosarcoma, soft tissue sarcomas, and lung, breast and bladder carcinomas. Loss of heterozygosity is a common mode in allelic inactivation of Rb and other tumor-suppressor genes. We investigat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90099-u
更新日期:1993-07-30 00:00:00
abstract::The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90092-1
更新日期:1982-05-01 00:00:00
abstract::Radiofrequency ablation (RFA) is widely accepted as a first-line interventional oncology approach for hepatocellular carcinoma (HCC) and has the advantages of high treatment efficacy and low complication risk. Local control rates equivalent to hepatic resection can be reached by RFA alone when treating small HCCs (<2 ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.09.020
更新日期:2016-01-01 00:00:00
abstract::By virtue of being a localized treatment modality, radiotherapy is unable to deliver a tumoricidal radiation dose to tissues outside of the irradiated field. Nevertheless, ionizing radiation may result in radiation damage mediated by a bystander like effect away from the irradiated field, but this response is likely t...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.04.007
更新日期:2015-11-28 00:00:00
abstract::Artemisinin, a compound isolated from the sweet wormwood Artemisia annua L., has previously been shown to have selective toxicity towards cancer cells in vitro. In the present experiment, we studied the potential of artemisinin to prevent breast cancer development in rats treated with a single oral dose (50mg/kg) of 7...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.01.019
更新日期:2006-01-08 00:00:00
abstract::Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90091-b
更新日期:1990-10-08 00:00:00
abstract::Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90014-3
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.09.016
更新日期:2016-01-01 00:00:00
abstract::Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.03.035
更新日期:2018-07-01 00:00:00
abstract::The number of Krebs II tumour cells recovered from the ascitic fluid of mice fed for 8 days on a lactalbumin (La) control diet was about three times higher than that in animals fed a phytohaemagglutinin-containing (PHA) diet. Feeding a PHA diet for less than 8 days after tumour cell injection also led to a reduction i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00316-9
更新日期:1997-12-16 00:00:00
abstract::We demonstrate herein the ability of transforming growth factor-beta-2 (TGFbeta2) to potently activate extracellular signal-regulated kinase 2 (ERK2) in the highly TGFbeta-sensitive breast cancer cell (BCC) line Hs578T. The ERK2 isoform was activated by 3-fold within 5 min of TGFbeta2 addition to Hs578T cells. However...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00211-5
更新日期:1997-07-15 00:00:00
abstract::Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.026
更新日期:2016-05-01 00:00:00
abstract::The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90045-0
更新日期:1987-05-01 00:00:00
abstract::A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.04.009
更新日期:2006-05-08 00:00:00
abstract::Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90132-h
更新日期:1990-01-01 00:00:00
abstract::The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90092-a
更新日期:1992-03-31 00:00:00
abstract::Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90090-6
更新日期:1994-03-15 00:00:00
abstract::Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.08.008
更新日期:2010-12-28 00:00:00
abstract::Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm2) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosis factor-related ap...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.10.017
更新日期:2019-01-01 00:00:00
abstract::Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00229-3
更新日期:1999-10-18 00:00:00
abstract::We investigated whether the level of bone marrow-derived progenitor cells and mature endothelial cells could be used as predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer. Peripheral blood mononuclear cells were obtained from 49 gastric cancer patients who rece...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.05.011
更新日期:2008-11-08 00:00:00
abstract::Fas/APO-1/CD95, a member of the tumor necrosis factor (TNF) receptor superfamily, is a potential anti-cancer factor as it can induce apoptosis in tumor cells. However, despite the fact that many cancer cells express Fas on the membrane, some tumors such as prostate cancer display resistance to Fas-induced apoptosis. I...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.06.006
更新日期:2010-12-01 00:00:00
abstract::Ring1 and YY1 binding protein (RYBP) is a member of the Polycomb group (PcG) proteins and regulates cell growth through both PcG-dependent and -independent mechanisms. Our initial study indicated that RYBP is down-regulated in human non-small cell lung cancer (NSCLC) tissues. The present study determined the molecular...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.09.003
更新日期:2015-12-28 00:00:00
abstract::In a comparative experimental study, excisions of a transplanted Lewis lung carcinoma in BDF1 mice were performed by means of the CO2 laser and conventional methods, namely common scalpel and diathermy. The results showed a significant reduction in tumor recurrence and animal mortality rates (27.5% vs. 75% and 45%) af...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(76)80009-2
更新日期:1976-09-01 00:00:00
abstract::The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03893-2
更新日期:1995-08-16 00:00:00
abstract::Matrix metalloproteinases (MMPs) are an homologous family of proteolytic enzymes capable of degrading components of the extracellular matrix (ECM) and thereby facilitating the invasion of tumour cells into normal tissues. The neural cell adhesion molecules (NCAMs) of neuronal and glial cells provide a Ca2+-independent...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00171-7
更新日期:1997-06-03 00:00:00
abstract::Although patients with localized and regional kidney tumors have a high survival rate, incidence of mortality significantly increases for patients with metastatic disease. It is imperative to decipher the molecular mechanisms of kidney tumor migration and invasion in order to develop effective therapies for patients w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.01.022
更新日期:2012-07-01 00:00:00