Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat.

abstract：:YM529, a new third generation bisphosphonate, induced apoptosis of a human breast cancer cell line, MX-1. Cytotoxic activity of YM529 was more potent than that of incadronate. YM529 activated caspase-9, but not caspase-8, and induced the release of cytochrome c into cytosol. YM529 increased Bax expression and decrease...

journal_title：Cancer letters

authors： Nakajima H,Magae J,Tsuruga M,Sakaguchi K,Fujiwara I,Mizuta M,Sawai K,Yamagishi H,Mizuta N

更新日期：2007-08-08 00:00:00

abstract：:Cultures of normal human peripheral blood lymphocytes stimulated by phytohaemagglutinin (PHA) were treated with withaferin A and examined by an electron microscope. The compound was found to affect the spindle microtubules of cells in metaphase. There were no intact pole-to-pole microtubules or pole-to-kinetochore mic...

journal_title：Cancer letters

authors： Shohat B,Ben-Bassat M,Shaltiel A,Joshua H

更新日期：1976-11-01 00:00:00

abstract：:BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intr...

journal_title：Cancer letters

authors： Hardy B,Morgenstern S,Raiter A,Rodionov G,Fadaeev L,Niv Y

更新日期：2005-11-18 00:00:00

abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...

journal_title：Cancer letters

authors： Defferrari R,Tonini GP,Conte M,Papio F,Sementa AR,Valent A,Schena F,Perri P,Mazzocco K

更新日期：2007-10-18 00:00:00

abstract：:The capacity of enteric bacteria (E. coli, Salmonella, Pseudomonas, Shigella and Klebsiella) to catalyze the covalent binding of benzo(a)pyrene (BP), cholic acid, deoxycholic acid and cholesterol was investigated. In general, these bacteria were incapable of activating BP to a covalently bound product with calf thymus...

journal_title：Cancer letters

authors： Zachariah PK,Slaga TJ,Berry DL,Bracken WM,Buty SG,Martinsen CM,Juchau MR

更新日期：1977-07-01 00:00:00

abstract：:Development of antiandrogen-resistance in advanced prostate cancer involves multiple androgen receptor (AR)-dependent and -independent pathways. Here, we demonstrated that endothelial nitric oxide synthase (eNOS) exhibited an overexpression pattern in hormone-refractory prostate cancer and several models of advanced h...

journal_title：Cancer letters

authors： Yu S,Jia L,Zhang Y,Wu D,Xu Z,Ng CF,To KK,Huang Y,Chan FL

更新日期：2013-01-01 00:00:00

abstract：:Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....

journal_title：Cancer letters

authors： Anderson LM,Carter JP,Driver CL,Logsdon DL,Kovatch RM,Giner-Sorolla A

更新日期：1993-01-15 00:00:00

abstract：:Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combi...

journal_title：Cancer letters

authors： Zhao Y,Su C,Zhai H,Tian Y,Sheng W,Miao J,Yang J

更新日期：2012-03-28 00:00:00

abstract：:Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...

journal_title：Cancer letters

authors： Nakagawara A,Ohira M

更新日期：2004-02-20 00:00:00

abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

journal_title：Cancer letters

authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

更新日期：2012-01-01 00:00:00

abstract：:In the present study, we tested the hypothesis that a mild cerebral tissue injury promotes subsequent glioma invasion via activation of the ADAM17-EGFR-PI3K-Akt pathway. Mild injury was induced by photodynamic therapy (PDT), which employs tissue-penetrating laser light exposure following systemic administration of a t...

journal_title：Cancer letters

authors： Zheng X,Jiang F,Katakowski M,Zhang X,Jiang H,Zhang ZG,Chopp M

更新日期：2008-07-08 00:00:00

abstract：:To be capable of selective killing of tumor cells, the non-selective Pseudomonas aeruginosa exotoxin A must have its cell-binding domain inactivated or removed and then be chemically linked to, or genetically fused with, a specific targeting agent. In the present study, epsilon-NH2 groups of lysine residues of the cel...

journal_title：Cancer letters

authors： Bourdenet S,Doyonnas R,Vacheron MJ,Guinand M,Fasciotto B,Ristic A,Michel G,Cozzone AJ,Durkin JP,Whitfield JF

更新日期：1990-04-20 00:00:00

abstract：:The aim of this study was to evaluate diagnostic performance of radiomics models of MRI in the detection of differentiation degree (DD) and lymph node metastases (LNM) of extrahepatic cholangiocarcinoma (ECC). We retrospectively enrolled 100 patients with ECC confirmed by pathology from January 2011 to December 2018. ...

journal_title：Cancer letters

authors： Yang C,Huang M,Li S,Chen J,Yang Y,Qin N,Huang D,Shu J

更新日期：2020-02-01 00:00:00

abstract：:We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-...

journal_title：Cancer letters

authors： Sokoloski JA,Narayanan R,Sartorelli AC

更新日期：1998-03-13 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...

journal_title：Cancer letters

authors： Zhong H,Mabjeesh N,Willard M,Simons J

更新日期：2002-07-26 00:00:00

abstract：:Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biologi...

journal_title：Cancer letters

authors： Kumar A,Deep G

更新日期：2020-09-28 00:00:00

abstract：:Many members of BCL2 (Bcl-2) apoptosis-related genes were found to be differentially expressed in various malignancies and were proposed as prognostic cancer biomarkers. Recently, a new member of the BCL2 gene family, BCL2L12, was cloned and was found to be expressed in mammary gland. In the present study, 55 specimen...

journal_title：Cancer letters

authors： Thomadaki H,Talieri M,Scorilas A

更新日期：2007-03-08 00:00:00

abstract：:Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their ability to induce autophagy using a cell-based assay. 114 of the drugs were...

journal_title：Cancer letters

authors： Dyczynski M,Yu Y,Otrocka M,Parpal S,Braga T,Henley AB,Zazzi H,Lerner M,Wennerberg K,Viklund J,Martinsson J,Grandér D,De Milito A,Pokrovskaja Tamm K

更新日期：2018-10-28 00:00:00

abstract：:The di-methyl-, di-ethyl-, di-propyl-, di-normal butyl-, and di-iso-butyl-ethers of hematoporphyrin were synthesized and shown to possess chromatographic properties similar to those of the tumorlocalizing components of hematoporphyrin derivative (Hpd). The cellular uptake of these ethers, as well as their retention in...

journal_title：Cancer letters

authors： Moan J,Rimington C,Sommer S

更新日期：1987-03-01 00:00:00

abstract：:Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

journal_title：Cancer letters

authors： Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

更新日期：2004-07-16 00:00:00

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00

abstract：:Gastric juice samples of 71 patients undergoing upper gastrointestinal endoscopy were collected as well as saliva samples from 40 of these patients. Age, sex, endoscopic diagnosis and medication were recorded. The gastric juice samples were analyzed for the presence and quantity of individual volatile N-nitrosamines, ...

journal_title：Cancer letters

authors： Dallinga JW,Pachen DM,Lousberg AH,van Geel JA,Houben GM,Stockbrügger RW,van Maanen JM,Kleinjans JC

更新日期：1998-02-27 00:00:00

abstract：:The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...

journal_title：Cancer letters

authors： Ohgaki H,Vogeley KT,Kleihues P,Wechsler W

更新日期：1993-06-15 00:00:00

abstract：:The intrinsic limits of conventional ultrasound microbubble contrast agent greatly promoted the development and application of various nanomaterials for more efficient cancer ultrasound theranostics. Considerable successes have been achieved in the field of ultrasound molecular imaging and targeted therapy for tumor b...

journal_title：Cancer letters

authors： Zhou LQ,Li P,Cui XW,Dietrich CF

更新日期：2020-02-01 00:00:00

abstract：:To investigate characteristic of lung adenocarcinoma growth behavior, we have established a cell line (rat lung cancer in Nara (RLCNR)) from a tumor induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in a rat. This clone shows an epithelial cell morphology and grows as sheets in culture with an approximate doubling t...

journal_title：Cancer letters

authors： Tsujiuchi T,Mori T,Amanuma T,Tanaka N,Tsutsumi M

更新日期：2005-01-10 00:00:00

abstract：:Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone sub...

journal_title：Cancer letters

authors： Schemies J,Sippl W,Jung M

更新日期：2009-08-08 00:00:00

abstract：:A growing body of experimental evidence supports the view that certain human chromosomal fragile sites have roles to play in cancer. The principle lines of evidence are at the level of mutation mechanism and gene function. Most research in this area has previously focussed on the FRA3B common fragile site and the FHIT...

journal_title：Cancer letters

authors： O'Keefe LV,Richards RI

更新日期：2006-01-28 00:00:00

abstract：:Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic ...

journal_title：Cancer letters

authors： Mazzoni SM,Fearon ER

更新日期：2014-12-01 00:00:00

abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

journal_title：Cancer letters

authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

更新日期：1996-01-02 00:00:00