Abstract:
:BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hardy B,Morgenstern S,Raiter A,Rodionov G,Fadaeev L,Niv Ydoi
10.1016/j.canlet.2005.06.046keywords:
subject
Has Abstractpub_date
2005-11-18 00:00:00pages
217-22issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00652-Xjournal_volume
229pub_type
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